- View sweeps by clicking on an Analysis
Graph data point - Impose single and averaged sweeps
- Quarantine bad sweeps in reanalysis
- PopSpike Area, Amplitude & Latency
- Three types of Slope measurement
- Analyze all EPSPs in a sweep
- Special analyses of trains Rs measurement from unfiltered trace
- Convert WinLTP data files to ABF files
- Reanalysis of ABF, IBW and WCP files
| Population Spike Area, Amplitude and Latency |
There are several analysis
programs that can measure Population Spike Area, Amplitude and Latency.
However, to our knowledge, WinLTP is the only
acquisition program
(other than proprietary software for MEA systems) that can do
online Population Spike Area,
Amplitude and Latency analysis.
The PopSpike Amplitude is calculated as the amplitude from the PopSpike peak to the intersection with an interpolated tangent dotted line drawn between the pre-PopSpike peak to the post-PopSpike peak (shown be the solid vertical line in the figure below). PopSpike Latency is calculated as the time between the occurrence of stimulus pulse and the PopSpike peak. PopSpike Area is the area between the tangent line and the waveform underneath. PopSpike Amplitude and PopSpike Latency do not depend upon DC baseline or Peak Amplitude.
For more information see Section 4.11.9 in the on-line WinLTP Manual.
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Detection of Population Spike Amplitude, Area and Latency. Detection
occurs between the left and right brackets on the waveform.
The solid vertical line is the Population Spike Amplitude, and the
time between the stimulus pulse and the solid vertical line
is the Population Spike Latency.
The area between the tangent line and the waveform is
the Population Spike Area. |