Version 2.20b
Leading-Edge Features
Special Features
Ordinary Features
Additional Features
Papers using WinLTP and/or the LTP Program
(to November 3, 2015)


WinLTP and the LTP Program has been used in at least 513 publications from labs in China, Finland, France, Germany, Israel, Italy, Japan, Korea, Portugal, Russia, Saudi Arabia, Spain, Switzerland, UK and USA, and from 6 labs from the University of Bristol.

If you have published a paper using WinLTP or the LTP Program and it is not listed below would you please email us the publication name.  Many thanks to those who referenced these programs.  



WinLTP has been used in at least 158 publications.


158.  Banks PB, Burroughs AC, Barker GRI, Brown JT, Warburton EC and Bashir ZI  (2015)  Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmissiON.  Proc. Nat. Acad. Sci., 112:11096–11101; doi/10.1073/pnas.1512064112.

157.  Barnes SA, Pinto-Duarte A, Kappe A, Zembrzycki A, Metzler A, Mukamel EA, Lucero J, Wang X, Sejnowski TJ, Markou A and Behrens MM (2015) Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders.  Molecular Psychiatry, 20:1161–1172; doi:10.1038/mp.2015.113.

156.  Buscetia CL, Di Pietroa P, Riozzia B, Traficantea A, Biagionia F, Nisticò R, Fornai F, Battaglia G, Nicoletti F and Bruno V (2015)  5-HT2C serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological Research, 99:258–268.

155.  De Filippis B, Chiodi V, Adriani W, Lacivita E, Mallozzi C, Leopoldo M, Domenici MR, Fuso A and Laviola G (2015) Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. Front. Behav. Neurosci., 9:86, doi: 10.3389/fnbeh.2015.0008.

154.  De Filippisa B, Valenti D, Chiodi V, Ferrante A, de Bari L, Fiorentini C, Domenici MR, Ricceri L, Vacca RA, Fabbri A and Laviola G (2015) Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome. European Neuropsychopharmacology, 25:889–90

153.  Dubal DB, Zhu L, Sanchez PE, Worden1 K, Broest L, Johnson E, Ho K, Yu G-Q, Kim D, Betourne A, Kuro-o M, Masliah E, Abraham CR and Mucke L (2015) Life extension factor Klotho prevents mortality and enhances cognition in hAPP transgenic mice. J. Neurosci., 35:2358-2371; doi: 10.1523/JNEUROSCI.5791-12.2015.

152.  Jiang Z-J, Wang C-Y, Xie X, Yang J-F, Huang J-N, Cao Z-P, Xiao P and Li C-H (2015) Schizandrin ameliorates ovariectomy-induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties. British J. Pharmacol., 172:2479–2492, DOI: 10.1111/bph.13078.

151.  Kang M, Ryu H-H and Lee Y-S (2015) Comparisons of behavior and synaptic plasticity among three C57BL/6 substrains. Animal Cells and Systems, DOI:10.1080/19768354.2015.1023830, pages 181-187.

150.  Kariharan T, Nanayakkara G, Parameshwaran K, Bagasrawala I, Ahuja M, Abdel-Rahman E, Amin AT, Dhanasekaran M, Suppiramaniam V and Amin RH (2015) Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression. Neurobiology of Aging, 36:1451–1461.

149.  Laing MD AND Bashir ZI (2015) Presynaptic NR2A-Containing NMDARs Are Required for LTD between the Amygdala and the Perirhinal Cortex: A Potential Mechanism for the Emotional Modulation of Memory? eNeuro, DOI: 10.1523/ENEURO.0046-14.2015

148.  Lee K, Kobayashi Y, Seo H, Kwak J-H, Masuda A, Lim C-S, Lee H-R, Kang SJJ, Park P, Sim S-E, Kogo N, Kawasaki H, Kaang B-K and Itohara S (2015) Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Molecular Brain, 8:38; DOI 10.1186/s13041-015-0130-1.

147.  Lopes JP, Morato X, Souza C, Pinha C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA and Ciruela F (2015) The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. J. Neurochem., 134:135–146, DOI: 10.1111/jnc.13109.

146.  Lopatář J, Dale N and Frenguelli BG (2015) Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations.  Neuropharmacology, 93:219–228; doi:10.1016/j.neuropharm.2015.01.014.

145.  Lipina TV, Prasad T, Yokomaku D, Luo L, Connor SA, Kawabe H, Wang YT, Brose N, Roder JC and Craig AM (2015) Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission. Neuropsychopharmacology, doi: 10.1038/npp.2015.206

144.  Mazzocchi-Jones D (2015) Impaired corticostriatal LTP and depotentiation following iPLA2 inhibition is restored following acute application of DHA.   Brain Res. Bulletin, 111:69–75.

143.  Parameshwaran K, Irwin MH, Steliou K, Suppiramaniam V and Pinkert CA  (2015)  Antioxidant-Mediated Reversal of Oxidative Damage in Mouse Modeling of Complex I Inhibition. Drug Development Research, 76:72–81, DOI: 10.1002/ddr.21242.

142.  Regan P, Piers T, Yi J-H, Kim D-H, Huh S, Park SJ, Ryu JH, Whitcomb DJ and Cho K (2015) Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD. J. Neurosci., 35:4804-4812; doi: 10.1523/JNEUROSCI.2842-14.2015.

141.  Ribeiro PO, Antunes LM, Nunes CS, Silva HB, Cunha RA and Tome AR (2015) The effects of different concentrations of the α2-adrenoceptor agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice  Anesthesia & Analgesia, 120:1130–1137.

140.  Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR and Morales M (2015) Norepinephrine Activates Dopamine D4 Receptors in the Rat Lateral Habenula.  J. Neurosci., 35:3460-3469; doi: 10.1523/JNEUROSCI.4525-13.2015.

139.  Saffarzadeh F, Eslamizade MJ, Ghadiri T, Mousav SMM, Hadjighassem M and Gorji A (2015) Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. Synapse, 69:375–383, DOI: 10.1002/syn.21825.

138.  Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez L-G, Gill TM, Sesaki H, Mucke L and Nakamura K (2015) Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death and Disease, 6:e1725; doi:10.1038/cddis.2015.94.

137.  Stancu I-C, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D and Dewachter I (2015) Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.  Acta Neuropathologica, 129:875-894.

136.  Wallis JL, Irvine MW, Jane DE, Lodge D, Collingridge and Bortolotto ZA (2015) An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.
Hippocampus, 25:1407–1417, DOI: 10.1002/hipo.22460.

135.  Wang H, Treadway T, Covey DP, Cheer JF and Lupica CR (2015) Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area.  Cell Reports, 12:1997–2008, doi:10.1016/j.celrep.2015.08.041.

134.  Wei P-J, Yao L-H. Dai D, Huang J-N, Liu W-X, Xiao P and Li C-H (2015) Tenuigenin enhances hippocampal Schaffer collateral-CA1 synaptic transmission through modulating intracellular calcium.  Phytomedicine, 22:807–812.

133.  Whitcomb DJ, Hogg EL, Regan P, Piers T, Narayan P, Whitehead G, Winters BL, Kim D-H, Kim E, St George-Hyslop P, Klenerman D, Collingridge GL, Jo J and Cho K  (2015)  Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus. Scientific Reports, 5:10934; doi:10.1038/srep10934.


132. Bernard PB, Castano AM, Bayer KU and Benke TA  (2014)  Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures.  Neuropharmacol., 84:1-12.

131.  Bhouri M, Farrow PA, Motee A, Yan X, Battaglia G, Di Menna L, Riozzi B, Nicoletti F, Fitzjohn SM and Bashir ZI  (2014)  mGlu1 Receptor-Induced LTD of NMDA Receptor Transmission Selectively at Schaffer Collateral-CA1 Synapses Mediates Metaplasticity.  J. Neuroscience, 34(36):12223–12229.

130.  Choi J-H, Park P, Baek GC, Sim SE, Kang SJJ, Lee Y, Ahn S-H, Lim C-S, Lee Y-S, Collingridge GL and Kaang B-K  (2014)  Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning,  Molecular Brain, 7:78.

129. Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AMM, Popoli P and Domenici MR  (2014)  Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP.  Neuropsychopharmacology, 39, 569–578.

128. Clarke VRJ, Molchanova SM, Hirvonen T, Taira T and Lauri SE (2014) Activity-Dependent Upregulation of Presynaptic Kainate Receptors at Immature CA3–CA1 Synapses. J. Neurosci., 34:16902-16916; doi: 10.1523/JNEUROSCI.1842-14.2014.

127.  Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu G-Q, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL and Mucke L  (2014)  Life Extension Factor Klotho Enhances Cognition.  Cell Reports, 7:1065-1076.

126.  Eom T, Muslimov IA, Tsokas P, Berardi V, Zhong J, Sacktor TC and Tiedge H (2014) Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control.  J. Cell Biology, 207:237-252; doi: 10.1083/jcb.201401005.

124. Félix-Oliveira A, Dias RB, Colino-Oliveira M, Rombo DM and Sebastião AM  (2014)  Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus. 

123.  Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE and Mucke L  (2014)  Tau Reduction Prevents Disease in a Mouse Model of Dravet Syndrome.  Ann. Neurology, DOI: 10.1002/ana.24230.

122. Jerónimo-Santos A, Batalha VL, Müller CE, Baqi Y, Sebastião AM, Lopes LV and Diógenes MJ  (2014)  Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.  Neuropharmacology, 83:99-106.

121. Jerónimo-Santos A, Vaz SA, Parreira S, Rapaz-Lérias S, Caetano AP, Buée-Scherrer V, Castrén E, Valente CA, Blum D, Sebastião AM and Diógenes MJ  (2014)  Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain.  Cerebral Cortex, doi:10.1093/cercor/bhu105.

120. Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A and Cho K  (2014)  Microtubule-associated protein tau is essential for long-term depression in the hippocampus.  Phil. Trans. R. Soc. B, 369:20130144,,

119.  Kumar M, Csaba1 Z, Peineau S, Srivastava1 R, Rasika S, Mani S, Gressens P and El Ghouzzi V (2014) Endogenous cerebellar neurogenesis in adult mice with progressive ataxia. Annals of Clinical and Translational Neurology, 1:968–981; DOI: 10.1002/acn3.137

118.  Lee HS, Ghettia A, Pinto-Duarte A, Wang X, Dziewczapolskia G, Galimi F, Huitron-Resendiz S, Piña-Crespo JC, Roberts AJ, Verma IM, Sejnowski TJ and Heinemann SF  (2014)  Astrocytes contribute to gamma oscillations and recognition memory.  PNAS,

116.  Lucantonio F, Takahashi YK, Hoffman AF, Chang CY, Bali-Chaudhary S, Shaham Y, Lupica CR and Schoenbaum G  (2014)  Orbitofrontal activation restores insight lost after cocaine use. Nature Neuroscience, 17:1092-1099, doi:10.1038/nn.3763.

115. Luchkina NV, Huupponen J, Clarke VRJ, Coleman SK, Keinänen K, Taira T and Lauri SE  (2014)  Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors.  PNAS, 111:4321-4326. 

114. Mango D, Barbato G, Piccirilli S, Panicoa MB, Feligioni M, Schepisi C, Graziani M, Porrini V, Benarese M, Lanzillotta A, Pizzi M, Pieraccini S, Sironi M, Blandini F, Nicoletti F, Mercuri MB, Imbimboi BP and Nisticò R  (2014)  Electrophysiological and metabolic effects of CHF5074 in thehippocampus: Protection against in vitro ischemia.  Pharmacological Research, 81:83–90.

113.  Mondal S, Sengupta T, Pradhan S, Hansda RN, Mandal PS, Tiwari R and Mukhopadhayay SK  (2014)  Impaired learning and memory after a week long exposure of acetamiprid in adult rats. Adv. Anim. Vet. Sci. 2:543-548. DOI |

112. Park P, Volianskis A, Sanderson TM, Bortolotto ZA, Jane DE, Zhuo M, Kaang B-K and Collingridge GL  (2014)  NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Phil. Trans. R. Soc. B, 369:20130131.

110.  Qi J, Zhang S, Wang H-L, Wang H, de Jesus Aceves Buendia J, Hoffman AF, Lupica CR, Seal RP and Morales M (2014) A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons. Nature Communications, 5:5390; doi:10.1038/ncomms6390.

109. Ribeiro PO, Tome AR, Silva HB, Cunha RA and Antunes LM  (2014)  Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.  Brain Res., 1560:10–17.

108. Rodrigues TM, Jerónimo-Santos A, Sebastião AM and Diógenes MJ  (2014)  Adenosine A2A Receptors as novel upstream regulators of BDNFmediated attenuation of hippocampal Long-Term Depression (LTD).  Neuropharmacol., 79:389-398.

107.  Root DH, Mejias-Aponte CA, Zhang S, Wang H-L, Hoffman AF, Lupica CR and Morales M (2014) Single rodent mesohabenular axons release glutamate and GABA. Nature Neuroscience, 17:1543–1551; doi:10.1038/nn.3823.

106. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JLR, Alvarez-Buylla A, and Huang Y  (2014)  Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A Accumulation.  J. Neurosci., 34:9506-9515.

  1. 105. Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM and Brandt SD  (2014)  Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers.  Drug Testing and Analysis, DOI: 10.1002/dta.1689.


104.  Bernard PB, Castano AM, O’Leary H, Simpson K, Browning MD and Benke TA  (2013)  Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.  Neurobiology of Disease, 59:1–17, doi:10.1016/j.nbd.2013.06.013.

103. Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG and  Wang YT  (2013)  Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells.  PLoS ONE 8(10): e76860. doi:10.1371/journal.pone.0076860.

102. Crabtree JW, Lodge D, Bashir ZI and Isaac JTR (2013)  GABAA, NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus.  Eur. J. Neurosci., 37:850–859.

101. Doherty GH, Beccano-Kelly D, Du Yanc S, Gunn-Moorea FJ and Harvey J  (2013)  Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β. Neurobiology of Aging 34:226–237.

100. Felici R, Lapucci A, Ramazzotti M and Chiarugi A  (2013)  Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria. PLoS ONE 8(10):e76938, doi:10.1371/journal.pone.0076938

99. Good CH, Wang H, Chen Y-H, Mejias-Aponte CA, Hoffman AF and Lupica CR  (2013)  Dopamine D4 Receptor Excitation of Lateral Habenula Neurons via Multiple Cellular Mechanisms.  J. Neurosci., 33:16853–16864.

98.  González-Sepúlveda M, Rosell S, Hoffmann HM, del Mar Castillo-Ruiz M, Mignon V, Moreno-Delgado D, Vignes M, Díaz J, Sabriá J, Ortiz J  (2013)  Cellular distribution of the histamine H3 receptor in the basal ganglia: Functional modulation of dopamine and glutamate neurotransmission.  Basal Ganglia, 3:109-121.

  • 97. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z and Lodge D  (2013)  Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.  Neuropharmacol., 66:114-121.

96.  Huang Y, Hu Z, Liu G, Zhou W and Zhang Y  (2013)  Cytokines induced by long-term potentiation (LTP) recording: A potential explanation for the lack of correspondence between learning/memory performance and LTP.  Neuroscience, 231:432–443.

95. Latour A, Grintal B, Champeil-Potokar G, Hennebelle M, Lavialle M, Dutar P, Potier B, Billard J-M, Vancassel S, Denis I  (2013)  Omega-3 fatty acids deficiency aggravates glutamatergic synapse and astroglial aging in the rat hippocampal CA1.  Aging Cell, 12:76–84.

94. Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA and Collingridge GL  (2013)  Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.  Neuropharmacol., 74:135–146.

93. Lucas SJ, Bortolotto ZA, Collingridge GL and Lodge D  (2013)  Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala. Neuropharmacol., 66:196–201.

92. Luchkina NV, Sallert M, Clarke VRJ, Taira T and Lauri SE  (2013)  Mechanisms underlying induction of LTP-associated changes in short-term dynamics of transmission at immature synapses.  Neuropharmacol., 67:494-502.

91. Martin S, Zekri L, Metz A, Maurice T, Chebli H, Vignes M and Tazi j  (2013)  Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons.  J. Neurochem., 125:175–184.

90. Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA  (2013)  Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. Neuropharmacol., 67:294–303.

89. Panaccione I, King R, Molinaro G, Riozzi B, Battaglia G, Nicoletti F and Bashir ZI  (2013)  Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex.  Neuropharmacol., 66:143–150.

88. Pettem KL, Yokomaku D, Luo L, Linhoff MW, Prasad T, Connor SA, Siddiqui TJ, Kawabe H, Chen F, Zhang L, Rudenko G, Wang YT, Brose N and Craig AM  (2013)  The Specific a-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development.  Neuron, 80:113–128.

87. Reich CG, Mihalik GR, Iskander AN, Seckler JC AND Weiss MS  (2013)  Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity.  Neuroscience, 253:444-454.

86. Rocca DL, Amici M, Antoniou A, Suarez EB, Halemani N, Murk K, McGarvey J, Jaafari N, Mellor JR, Collingridge GL and Hanley JG  (2013)  The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity.  Neuron, 79:293–307.

85. Rosenberg D, Artoul S, Segal AC, Kolodney G, Radzishevsky I, Dikopoltsev E, Foltyn VN, Inoue R, Mori H, Billard J-M, and Wolosker H  (2013)  Neuronal d-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity  J. Neurosci., 33:3533-3544.

84. Scattoni ML, Martire A, Cartocci G, Ferrante A and Ricceri L  (2013)  Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism,  Behavioural Brain Research,

83. Siddiqui TJ, Tari PK, Connor SA, Zhang P, Dobie FA, She K, Kawabe H, Wang YT, Brose N and Craig AM  (2013)  An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells.  Neuron, 79:680–695.

82. Srivastava R, Kumar M, Peineau S, Csaba Z, Mani S, Gressems P and El Ghouzzi V  (2013)  Conditional Induction of Math1 Specifies Embryonic Stem Cells to Cerebellar Granule Neuron Lineage and Promotes Differentiation into Mature Granule Neurons.  Stem Cells, 31:652–665.

81. Sonner PM and Ladle DR  (2013)  Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord.  J. Neurophysiol. 109:2118-2128.

80. Tamagnini F, Barker GRI, Warburton CE, Burattini C, Aicardi G and Bashir Z  (2013)  Nitric oxide-dependent LTD but not endocannabinoid-LTP is crucial for visual recognition memory. J. Physiol., 591:3963-3979, 10.1113/jphysiol.2013.254862.

79. Titus DJ, Furones C, Kang Y and Atkins CM  (2013)  Age-Dependent Alterations in cAMP Signaling Contribute to Synaptic Plasticity Deficits Following Traumatic Brain Injury. Neuroscience, 231:182–194. doi:10.1016/j.neuroscience.2012.12.002.

78. Titus DJ, Sakurai A, Kang Y, Furones C, Jergova S, Santos R, Sick TJ and Atkins CM  (2013)  Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury.  J. Neurosci., 33:5216-5226.

77. Villers A and Ris L  (2013)  Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation.  JoVE (Journal of Visualized Experiments), doi: 10.3791/50483.

76.  Whitehead G, Jo J, Hogg EL, Piers T, Kim D-H, Seaton G, Seok H, Bru-Mercier G, Son GH, Regan P, Hildebrandt L, Waite E, Kim B-C, Kerrigan TL, Kim K, Whitcomb DJ, Collingridge GL, Lightman SL and Cho K  (2013)  Acute stress causes rapid synaptic insertion of Ca2+-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.  Brain, 136:3753–3765.


  • 75. Ceolin L, Bortolotto ZA, Bannister N, Collingridge GL, Lodge D and Volianskis A  (2012)  A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus.  Neurochemistry International, 61:517-522.

74. Clarke VRJ, Collingridge GL, Lauri SE and Taira T  (2012)  Synaptic kainate receptors in CA1 interneurons gate the threshold of theta-frequency-induced long-term potentiation.  J. Neurosci., 32:18215-18226.

73. Colotta V, Lenzi O, Catarzi D, Varano F, Squarcialupi L, Costagli C, Galli A, Ghelardini C, Pugliese AM, Maraula G, Coppi E, Pellegrini-Giampietro DE, Pedata F, Sabbadin D and Moro S  (2012)  3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies.  Eur. J. Med. Chem., 54:470–482.

72. Dias RB, Ribeiro JA and Sebastião AM  (2012)  Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A2A receptors.  Hippocampus, 22:276–291.

71. Diógenes MJ, Dias RB, Rombo DM, Miranda HV, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LMA, Castanho MARB, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV and Outeiro TF  (2012)  Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.  J. Neurosci., 32:11750-11762.

70. Freret T, Billard J-M, Schumann-Bard P, Dutar P, Dauphin F, Boulouard M and Bouet V  (2012)  Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.  Neurobiology of Aging, 33:1005.e1–1005.e10.

69. Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G?, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnar E, Monaghan DT, Jane DE (2012) Piperazine-2,3-dicarboxylic Acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors. J. Med. Chem., 55:327-341.

68. Haxaire C, Turpin FR, Potier B, Kervern M, Sinet P-M, Barbane G, Mothet J-P, Dutar P, Billard J-M (2012) Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation. Aging Cell, 11:336–344.

67. Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TMK, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD and Bahn S  (2012) The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus.  Neuropsychopharmacology, 37:364–377

66. Huang Y, Yang S, Hu Z-Y, Liu G, Zhou W-X and Zhang Y-X  (2012)  A new approach to location of the dentate gyrus and perforant path in rats/mice by landmarks on the skull  Acta Neurobiol. Exp., 468–472.

65. Huang Y, Zhang H, Yang S, Qiao H, Zhou W and Zhang Y  (2012)  Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors. J. Ethnopharm., 140:384–390.

64.  Huupponen, J, Molchanova SM, Lauri SE and Taira T  (2012)  Ongoing intrinsic synchronous activity is required for the functional maturation of CA3-CA1 glutamatergic synapses.  Cerebral Cortex, doi: 10.1093/cercor/bhs262.

63. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y  (2012)  Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.  PLoS ONE 7(9): e46340. doi:10.1371/journal.pone.0046340.

62. Kaindl AM, Degos V, Peineau S, Gouadon E, Chhor V, Loron G, Le Charpentier T, Josserand J, Ali C, Vivien D, Collingridge GL, Lombet A, Issa L, Rene F, Loeffler JP, Kavelaars A, Verney C, Mantz J and Gressens P  (2012)  Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.  Ann. Neurology, 72:536–549.

61. Kratzer S, Mattusch C, Kochs E, Eder M, Haseneder R and Rammes Gerhard  (2012)  Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents. Anesthesiology, 116:673-682.

  • 60. Lucas SJ, Bortolotto ZA, Collingridge GL and Lodge D  (2012)  Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.  Neuropharmacology, in press.

59. Luchkina NV, Sallert M, Clarke VRJ, Taira T and Lauri SE  (2012)  Mechanisms underlying induction of LTP-associated changes in short-term dynamics of transmission at immature synapses.  Neuropharmacol., 67:494-502.

58. Muzzi M, Blasi F, Masi A, Coppi E, Traini C, Felici R, Pittelli M, Cavone L, Pugliese AM, Moroni F and Chiarugi A  (2012)  Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.  J. Cerebral Blood Flow & Metabolism, doi:10.1038/jcbfm.2012.157.

57. Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi S-L, Sim S-E, Bradley C, Lee K, Zhuo M, Kaang B-K, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K and Collingridge GL  (2012)  The JAK/STAT Pathway Is Involved in Synaptic Plascity.  Neuron, 73:374–390.

56. Nuritova F and Frenguelli BG  (2012)  Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors.  Neurosci., 222:159-172.

  • 55. Panaccione I, King R, Molinaro G, Riozzi B, Battaglia G, Nicoletti F and Bashir ZI  (2012) Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex.  Neuropharmacology, in press.

54. Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E and Vivien  (2012)  Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.  Cell Death & Differentiation, 19:1983-1991.

53. Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA and Smolders I  (2012)  Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents. Neurotherapeutics, 9:658-672.

52. Regnier V, Billard J-M, Gupta S, Potier B, Woerner S, Paly E, Aurelie Ledru, David S, Luilier S, Bizot J-C, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, London J (2012) Brain Phenotype of Transgenic Mice Overexpressing Cystathionine b-Synthase. PLOS ONE, 7:e29056.

51. Romberg C, McTighe SM, Heath CJ, Whitcomb DJ, Cho K, Bussey TJ and Saksida LM  (2012)  False recognition in a mouse model of Alzheimer’s disease: rescue with sensory restriction and memantine.  Brain, doi:10.1093/brain/aws074.

50.  Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ and Mucke L  (2014)  Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model.  Proc. Nat Acad Sci., 109:2895-2903.

49. Sanderson TM, Cotel MC, O’Neill MJ, Tricklebank MD, Collingridge GL and Sher E  (2012)  Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.  Neuropharmacology, 62:1349-1358.

48. Scott   HL, Tamagnini F, Narduzzo KE, Howarth JL, Lee YB, Wong LF, Brown MW, Warburton EC, Bashir ZI and Uney JB  (2012)  MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.  Eur. J Neurosci., 36: 2941–2948.

47. Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA  (2012)  Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.  Neurochemistry International, 61:482-489.

46. Shonesy BC, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amina R,  Dhanasekaran M and Suppiramaniam V  (2012)  Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents.  Neurobiology of Aging, 33:430.e5– 430.e18.

45. Srivastava R, Kumar M, Peineau S, Csaba Z, Mani S, Gressens P, El Ghouzzi V  (2012)  Conditional induction of Math1 specifies embryonic stem cells to cerebellar granule neuron lineage and promotes differentiation into mature granule neurons.  Stem Cells,  31:652–665.

44. Supcun B, Ghadiri MK, Zeraati M, Stummer W, Speckmann EJ, Gorji A  (2012)  The effects of tetanic stimulation on plasticity of remote synapses in the hippocampus-perirhinal cortex-amygdala network.  Synapse, 66:965-974.

43. Titus DJ, Furones C, Kang Y,  Atkins CM  (2013)  Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.  Neuroscience, 231:182-194.

42. Villers A, Godaux E, Ris L (2012) Long-Lasting LTP Requires Neither Repeated Trains for Its Induction Nor Protein Synthesis for Its Development. PLoS ONE 7(7): e40823. doi:10.1371/journal.pone.0040823


41. Bartlett TE, Lu J and Wang YT  (2011)  Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.  Mol. Brain, 4:41.

40. Bouet V, Freret T, Dutar P, Billard J-M, Boulouard M (2011) Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals. Mechanisms of Ageing and Development, 132:240-248.

39. Caruana DA, Warburton ED, Bashir ZI (2011) Induction of Activity-Dependent LTD Requires Muscarinic Receptor Activation in Medial Prefrontal Cortex. J. Neurosci., 31:18464-18478.

38. Ceolin L, Kantamneni S, Barker GRI, Hanna L, Murray L, Warburton EC, Robinson ESJ, Monn JA, Fitzjohn SM, Collingridge GL,  Bortolotto ZA and Lodge D  (2011)  Study of Novel Selective mGlu2 Agonist in the Temporo-Ammonic Input to CA1 Neurons Reveals Reduced mGlu2 Receptor Expression in a Wistar Substrain with an Anxiety-Like Phenotype.  J. Neurosci., 31:6721– 6731.

37. Errico F, Nisticò R, Napolitano F, Mazzola C, Astone D, Pisapia T, Giustizieri M, D’Aniello A, Mercuri NB, Usiello A  (2011)  Increased d-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.  Neurobiol. Aging, 32:2229–2243.

36. Escobar M , Crouzin N , Cavalier M , Quentin J , Roussel J , Lanté F , Batista-Novais AR , Cohen-Solal C , De Jesus Ferreira M-C , Guiramand J , Barbanel G and Vignes M  (2011)  Early, Time-Dependent Disturbances of Hippocampal Synaptic Transmission and Plasticity After In Utero Immune Challenge.  Biol. Psychiatry, 70:992–999.

35. Gan J, Greenwood SM, Cobb SR and Bushell TJ  (2011)  Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.  Brit. J. Pharmacol, 163:984-994.

34. Kim J-I, Lee H-R, Sim S, Baek J, Yu N-K, Choi J-H, Ko H-G, Lee Y-S, Park S-W, Kwak C, Ahn S-J, Choi SY, Kim H, Kim K-H,  Backx PH, Bradley CA, Kim E, Jang D-J, Lee K, Kim SJ, Zhuo M, Collingridge GL and Kaang B-K  (2011)  PI3Kg is required for NMDA receptor–dependent long-term depression and behavioral flexibility.  Nature Neuroscience, 14:1447–1454.

33.  Koch S, Molchanova SM, Wright AK, Edwards A, Cooper JD, Taira T, Gillingwater TH, Tyyne J (2011) Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis. J. Neuropathology & Experimental Neurology, 70:1089-1096.

32. Min J-A, Lee H-R, Kim J-I, Jub A, Kim D-J, Kaang B-K  (2011)  Impairment of long-term potentiation in the hippocampus ofalcohol-treated OLETF rats.  Neuroscience Letters, 500:52-56.

31. Moult PR and Harvey J  (2011)  NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity.  Neuropharmacology, 61:924-936.

30. Sanderson TM, Collingridge GL and Fitzjohn SM  (2011)  Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs  Molecular Brain, 4:30.

29. Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH and Craig AM  (2011)  Postsynaptic TrkC and Presynaptic PTPs Function as a Bidirectional Excitatory Synaptic Organizing Complex.  Neuron, 69, 287–303.

28. Weng S-M, McLeod F, Bailey MES and Cobb SR (2011)  Synaptic Plasticity Deficits in an Experimental Model of Rett Syndrome: Long-Term Potentiation Saturation and its Pharmacological Reversal.  Neuroscience 180:314–321.


27. Armogida M, Giustizieri M, Zona C, Piccirilli S, Nisticò R, Mercuri NB  (2010)  N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: An in vitro electrophysiological study.  Synapse, 64:161-168.

26. Potier B, Billard J-M, Rivière S, Sinet P-M, Denis I, Champeil-Potokar G, Grintal B, Jouvenceau A, Kollen M, Dutar P  (2010)  Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.  Aging Cell, 9:722–735.

25. Hoffman AF, Laaris N, Kawamura M, Masino SA, Lupica CR  (2010)  Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A1 Receptors.  J. Neurosci., 30:545-555.

24. Jo J, Son GH, Winters BL, Kim MJ, Whitcomb DJ, Dickenson BA, Lee Y-B, Futai K, Amici M, Sheng M, Collingridge GL and Cho K  (2010)  Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.  Nature, 13:1216–1224.

23. Kamsler A, McHugh TJ, Gerber D, Huang SY, Tonegawa S  (2010)  Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.  PNAS, 107:1618-1623.

22. Lagostena L, Rosato-Siri M, Onofrio M, Brandi R, Arisi I, Capsoni S, Franzot J, Cattaneo A, Cherubini E  (2010)  In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction.  J. Neurosci., 30:885-893.

21. Moult PR, Cross A, Santos SD, Carvalho A-L, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J  (2010)  Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition.  J. Neurosci., 30:4088-4101.

20. Villers A, Godaux E, Ris L  (2010)  Late phase of L-LTP elicited in isolated CA1 dendrites cannot be transferred by synaptic capture.  NeuroReport, 21:210-215.


19. Dargan SL, Clarke VRJ, Alushin GM, Sherwood JL, Nistico R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL  (2009)  ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function.  Neuropharmacol., 56:121-130.

18. Hong I, Song B, Lee S, Kim J, Kim J, Choi S  (2009)  Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala.  Eur. J. Neurosci., 30:2089-2099.

17. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM, Backman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brene S, Olson L  (2009)  Nogo receptor 1 regulates formation of lasting memories.  PNAS, 106:20476-20481.

16. Kim J, Park S, Lee S and Choi S  (2009)  Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis.  Neuroreport, 20:517-520.

15. Lagostena L, Danober L, Challal S, Lestage P,  Mocaër E, Trocmé-Thibierge C, Cherubini E  (2009)  Modulatory effects of S 38232, a non α-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus.  Neuropharmacol., 58:806-815.

14. Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A  (2009)  Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.  Brain, 132:2336-2349.

13. Omrani A, Melone M, Bellesi M, Safiulina V, Aida T, Tanaka K, Cherubini E, Conti F  (2009)  Up-regulation of GLT-1 severely impairs LTD at mossy fibre-CA3 synapses.  J. Physiol., 587:4575-4587.

12. Peineau S, Nicolas CS, Bortolotto ZA, Bhat RV, Jonathan Ryves W, Harwood AJ, Dournaud P, Fitzjohn SM, Collingridge GL  (2009)  A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.  Mol. Brain, 2:22 (10 pages).

11. Ris L, Villers A, Godaux E  (2009)  Synaptic capture-mediated long-lasting long-term potentiation is strongly dependent on mRNA translation.  NeuroReport, 20:1572-1576.

10. Sallert M, Rantamaki T, Vesikansa A, Anthoni H, Harju K, Yli-Kauhaluoma J, Taira T, Castren E, Lauri SE  (2009)  Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1 Synapses by Downregulating Tonic Activation of Presynaptic Kainate Receptors.  J. Neurosci., 29:11294-11303.

9. Seoane A, Massey PV, Keen H, Bashir ZI, Brown MW  (2009)  L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes.  J. Neurosci., 29:9534-9544.

8. Zadran S, Qin Q, Bi X, Zadran H, Kim Y, Foy MR, Thompson R, Baudry M  (2009)  17-β-Estradiol increases neuronal excitability through MAP kinase-induced calpain activation PNAS, 106:21936-21941.


7. Fernandes CC, Pinto-Duarte A, Ribeiro JA, and Sebastiao AM  (2008)  Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.  J. Neurosci., 28:5611–5618.

6. Jo J, Heon S, Kim MJ, Son GH, Park Y, Henley JM, Weiss JL, Sheng M, Collingridge GL and Cho K  (2008)  Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1.  Neuron, 60:1095-1111.

5. Lagostena L, Trocme-Thibierge C, Morain P and Cherubini E  (2008)  The partial a7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus.  Neuropharmacol., 54:676-685.

4. Giustizieri M, Armogida M, Berretta N, Federici M, Piccirilli S, Mercuri NB, Nistico R (2008)  Differential effect of carbamazepine and oxcarbazepine on excitatory synaptic transmission in rat hippocampus. Synapse 62:783–789.

3. Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Kunzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM and Boddeke HWGM  (2008)  Interleukin-6 upregulates neuronal Adenosine A1 receptors: Implications for neuromodulation and neuroprotection.     Neuropsychopharmacol., 33:2237-2250.


2. Lanté F, Meunier J, Guiramand J, Maurice T, Cavalier M, de Jesus Ferreira MC, Aimar R, Vignes M and Barbanel G (2007)  Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain.  Free Radical Biology and Medicine, 42:1231–1245.

1.  Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bortolotto ZA, Wang YT, Collingridge GL  (2007)  UP inhibits LTD in the hippocampus via regulation of GSK3 beta. Neuron, 53:703-717.



LTP Program

The LTP Program has been used in at least 355 publications.  


355.  Ahmed Z and Wieraszko A (2015) Pulsed magnetic stimulation modifies amplitude of action potentials in vitro via ionic channels-dependent mechanism. Bioelectromagnetics, 36:386–397, DOI: 10.1002/bem.21917.

354.  Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA and Rial D  (2015)  Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus.  Eur. J. Neurosci., 41:878–888; DOI: 10.1111/ejn.12851.

353.  Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Dami TE, Berti A, Stefani M and Casamenti F (2015) Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates. Neurobiology of Aging, 36:648–663; doi:10.1016/j.neurobiolaging.2014.08.029.

352.  Li W, Silva HB, Real J, Wang Y-M, Rial D, Li P, Payen M-P, Zhou Y, Muller CE, Tomé AR, Cunha RA and Chen J-F (2015) Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiology of Disease, 79:70–80; doi:10.1016/j.nbd.2015.03.030.

351.  Pál I, Kardos J, Dobolyi A and Héja L (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Molecular Brain, 8:35; DOI 10.1186/s13041-015-0127-9.

350.  Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Spanswick D, O'Hare E, Palmer P, Kim E-M, Bywalez W, Egger V and Parsons CG (2015) MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology, 92:170–182.

349.  Santos AR, Mele M, Vaz SH, Kellermayer B, Grimaldi M, Colino-Oliveira M, Rombo DM, Comprido D, Sebastião AM and Duarte CB (2015) Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP. J. Neurosci., 35:3319-3329; doi: 10.1523/JNEUROSCI.4521-14.2015.


348. Assaife-Lopes N, Sousa VC, Pereira DB, Ribeiro JA and Sebastião AM  (2014)  Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity.  Purinergic Signalling, 10:251–267.

 347.  Bhagya V, Srikumar BN, Raju TR and Shankaranarayana Rao BS  (2014)  The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression.  J. Neuroscience Research, DOI: 10.1002/jnr.23473.

346.  Cunha-Reis D, de Fatima Aidil-Carvalho M and Ribeiro JA  (2014)  Endogenous Inhibition of Hippocampal LTD and Depotentiation by Vasoactive Intestinal Peptide VPAC1 Receptors.  Hippocampus, DOI: 10.1002/hipo.22316.

345.  Ferrante A, Martire A, Pepponi R, Varani K, Vincenzi F, Ferraroc L, Beggiato S, Tebano MT and Popoli P  (2014)  Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease.  Neurobiology of Disease, 71:193–204.

344.  Fezza F, Marrone MC, Avvisati R, Di Tommaso M, Lanuti M, Rapino C, Mercuri NB, Maccarrone M and Marinelli S  (2014) Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.  Molecular and Cellular Neuroscience 62:1–9.

343.  Jiang Y, Liu Y, Zhu C, Ma X, Ma L, Zhou L, Huang Q, Cen L, Pi R and Chen X (2015) Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiology of Learning and Memory, 121:20–29, doi:10.1016/j.nlm.2015.03.003.

342.  Laing M and Bashir ZI  (2014)  β-Adrenoceptors and synaptic plasticity in the perirhinal cortex.  Neuroscience, 273:163-173.

341. Liu Q-Y, Wang C-Y, Cai Z-L, Xu S-T, Liu W-X, Xiao P and Li C-H  (2014)  Effects of intrahippocampal GABAB receptor antagonist treatment on the behavioral long-term potentiation and Y-maze learning performance.  Neurobiology of Learning and Memory, 114:26–31.

340. Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Dami TE, Berti A, Stefani M, Casamenti F  (2014)  Oleuropein aglycone protects against pyroglutamylated-3 Aß toxicity: biochemical, epigenetic and functional correlates.  Neurobiology of Aging, DOI: 10.1016/j.neurobiolaging.2014.08.029.

339.  Maraula G, Lana D, Coppi E, Gentile F, Mello T, Melani A, Galli A, Giovannini MG, Pedata F and Pugliese AM (2014) The Selective Antagonism of P2X7 and P2Y1 Receptors Prevents Synaptic Failure and Affects Cell Proliferation Induced by Oxygen and Glucose Deprivation in Rat Dentate Gyrus. PLOS|One, DOI: 10.1371/journal.pone.0115273.

338.  Nedden S, Doney AS and Frenguelli BG  (2014)  Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells.  J. Neurochem., 128:111-124.

337.  Rial D, Castro AA, Machado N, Garção P, Gonçalves FQ, Silva HB, Tomé AR, Köfalvi A, Corti O, Raisman-Vozari R, Cunha RA and Prediger RD (2014) Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease. PLOS|One, DOI: 10.1371/journal.pone.0114216.

336.  Ribeiro PO, Tome´ AR, Silva HB, Cunha RA and Antunes LM  (2014)  Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.  Brain Research, 1560:10–17.

 335.  Sousa VC, Vital J, Costenla AR, Batalha VL, Sebastião AM, Ribeiro JA and Lopes  lv  (2014)  Maternal separation impairs long term-potentiation in CA1-CA3 synapses and hippocampal-dependent memory in old rats. Neurobiology of Aging, 35:1680-1685.


334. Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean M-E, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D  (2013)  NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.  Aging Cell, 12:11–23.

333.  Ferreira AC, Pinto V, Dá Mesquita S, Novais A, Sousa JC, Correia-Neves M, Sousa N, Palha JA and Marques F  (2014)  Lipocalin-2 is involved in emotional behaviors and cognitive function.  Front. Cell Neurosci., 7:122.

332. Haseneder R, Starker L, Berkmann J, Kellermann K, Jungwirth B, Blobner M, Eder M, Kochs E and Rammes G (2013) Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum. PLoS ONE 8(5): e64732. doi:10.1371/journal.pone.0064732

331. Martire A, Pepponi R, Domenici MR, Ferrante A, Chiodi V, Popoli P  (2013)  BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.  J. Neurochem., 125:225-235.

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