WinLTP
Version 2.20b
Leading-Edge Features
Special Features
Ordinary Features
Additional Features
Sousa
 
Papers using WinLTP and/or the LTP Program
(to November 3, 2015)

 

WinLTP and the LTP Program has been used in at least 513 publications from labs in China, Finland, France, Germany, Israel, Italy, Japan, Korea, Portugal, Russia, Saudi Arabia, Spain, Switzerland, UK and USA, and from 6 labs from the University of Bristol.

If you have published a paper using WinLTP or the LTP Program and it is not listed below would you please email us the publication name.  Many thanks to those who referenced these programs.  

 

WinLTP

WinLTP has been used in at least 158 publications.

2015

158.  Banks PB, Burroughs AC, Barker GRI, Brown JT, Warburton EC and Bashir ZI  (2015)  Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmissiON.  Proc. Nat. Acad. Sci., 112:11096–11101; doi/10.1073/pnas.1512064112.

157.  Barnes SA, Pinto-Duarte A, Kappe A, Zembrzycki A, Metzler A, Mukamel EA, Lucero J, Wang X, Sejnowski TJ, Markou A and Behrens MM (2015) Disruption of mGluR5 in parvalbumin-positive interneurons induces core features of neurodevelopmental disorders.  Molecular Psychiatry, 20:1161–1172; doi:10.1038/mp.2015.113.

156.  Buscetia CL, Di Pietroa P, Riozzia B, Traficantea A, Biagionia F, Nisticò R, Fornai F, Battaglia G, Nicoletti F and Bruno V (2015)  5-HT2C serotonin receptor blockade prevents tau protein hyperphosphorylation and corrects the defect in hippocampal synaptic plasticity caused by a combination of environmental stressors in mice. Pharmacological Research, 99:258–268.

155.  De Filippis B, Chiodi V, Adriani W, Lacivita E, Mallozzi C, Leopoldo M, Domenici MR, Fuso A and Laviola G (2015) Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. Front. Behav. Neurosci., 9:86, doi: 10.3389/fnbeh.2015.0008.

154.  De Filippisa B, Valenti D, Chiodi V, Ferrante A, de Bari L, Fiorentini C, Domenici MR, Ricceri L, Vacca RA, Fabbri A and Laviola G (2015) Modulation of Rho GTPases rescues brain mitochondrial dysfunction, cognitive deficits and aberrant synaptic plasticity in female mice modeling Rett syndrome. European Neuropsychopharmacology, 25:889–90

153.  Dubal DB, Zhu L, Sanchez PE, Worden1 K, Broest L, Johnson E, Ho K, Yu G-Q, Kim D, Betourne A, Kuro-o M, Masliah E, Abraham CR and Mucke L (2015) Life extension factor Klotho prevents mortality and enhances cognition in hAPP transgenic mice. J. Neurosci., 35:2358-2371; doi: 10.1523/JNEUROSCI.5791-12.2015.

152.  Jiang Z-J, Wang C-Y, Xie X, Yang J-F, Huang J-N, Cao Z-P, Xiao P and Li C-H (2015) Schizandrin ameliorates ovariectomy-induced memory impairment, potentiates neurotransmission and exhibits antioxidant properties. British J. Pharmacol., 172:2479–2492, DOI: 10.1111/bph.13078.

151.  Kang M, Ryu H-H and Lee Y-S (2015) Comparisons of behavior and synaptic plasticity among three C57BL/6 substrains. Animal Cells and Systems, DOI:10.1080/19768354.2015.1023830, pages 181-187.

150.  Kariharan T, Nanayakkara G, Parameshwaran K, Bagasrawala I, Ahuja M, Abdel-Rahman E, Amin AT, Dhanasekaran M, Suppiramaniam V and Amin RH (2015) Central activation of PPAR-gamma ameliorates diabetes induced cognitive dysfunction and improves BDNF expression. Neurobiology of Aging, 36:1451–1461.

149.  Laing MD AND Bashir ZI (2015) Presynaptic NR2A-Containing NMDARs Are Required for LTD between the Amygdala and the Perirhinal Cortex: A Potential Mechanism for the Emotional Modulation of Memory? eNeuro, DOI: 10.1523/ENEURO.0046-14.2015

148.  Lee K, Kobayashi Y, Seo H, Kwak J-H, Masuda A, Lim C-S, Lee H-R, Kang SJJ, Park P, Sim S-E, Kogo N, Kawasaki H, Kaang B-K and Itohara S (2015) Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Molecular Brain, 8:38; DOI 10.1186/s13041-015-0130-1.

147.  Lopes JP, Morato X, Souza C, Pinha C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA and Ciruela F (2015) The role of parkinson's disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic system. J. Neurochem., 134:135–146, DOI: 10.1111/jnc.13109.

146.  Lopatář J, Dale N and Frenguelli BG (2015) Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations.  Neuropharmacology, 93:219–228; doi:10.1016/j.neuropharm.2015.01.014.

145.  Lipina TV, Prasad T, Yokomaku D, Luo L, Connor SA, Kawabe H, Wang YT, Brose N, Roder JC and Craig AM (2015) Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission. Neuropsychopharmacology, doi: 10.1038/npp.2015.206

144.  Mazzocchi-Jones D (2015) Impaired corticostriatal LTP and depotentiation following iPLA2 inhibition is restored following acute application of DHA.   Brain Res. Bulletin, 111:69–75.

143.  Parameshwaran K, Irwin MH, Steliou K, Suppiramaniam V and Pinkert CA  (2015)  Antioxidant-Mediated Reversal of Oxidative Damage in Mouse Modeling of Complex I Inhibition. Drug Development Research, 76:72–81, DOI: 10.1002/ddr.21242.

142.  Regan P, Piers T, Yi J-H, Kim D-H, Huh S, Park SJ, Ryu JH, Whitcomb DJ and Cho K (2015) Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD. J. Neurosci., 35:4804-4812; doi: 10.1523/JNEUROSCI.2842-14.2015.

141.  Ribeiro PO, Antunes LM, Nunes CS, Silva HB, Cunha RA and Tome AR (2015) The effects of different concentrations of the α2-adrenoceptor agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice  Anesthesia & Analgesia, 120:1130–1137.

140.  Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR and Morales M (2015) Norepinephrine Activates Dopamine D4 Receptors in the Rat Lateral Habenula.  J. Neurosci., 35:3460-3469; doi: 10.1523/JNEUROSCI.4525-13.2015.

139.  Saffarzadeh F, Eslamizade MJ, Ghadiri T, Mousav SMM, Hadjighassem M and Gorji A (2015) Effects of TRPV1 on the hippocampal synaptic plasticity in the epileptic rat brain. Synapse, 69:375–383, DOI: 10.1002/syn.21825.

138.  Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez L-G, Gill TM, Sesaki H, Mucke L and Nakamura K (2015) Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death and Disease, 6:e1725; doi:10.1038/cddis.2015.94.

137.  Stancu I-C, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D and Dewachter I (2015) Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.  Acta Neuropathologica, 129:875-894.

136.  Wallis JL, Irvine MW, Jane DE, Lodge D, Collingridge and Bortolotto ZA (2015) An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.
Hippocampus, 25:1407–1417, DOI: 10.1002/hipo.22460.

135.  Wang H, Treadway T, Covey DP, Cheer JF and Lupica CR (2015) Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area.  Cell Reports, 12:1997–2008, doi:10.1016/j.celrep.2015.08.041.

134.  Wei P-J, Yao L-H. Dai D, Huang J-N, Liu W-X, Xiao P and Li C-H (2015) Tenuigenin enhances hippocampal Schaffer collateral-CA1 synaptic transmission through modulating intracellular calcium.  Phytomedicine, 22:807–812.

133.  Whitcomb DJ, Hogg EL, Regan P, Piers T, Narayan P, Whitehead G, Winters BL, Kim D-H, Kim E, St George-Hyslop P, Klenerman D, Collingridge GL, Jo J and Cho K  (2015)  Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus. Scientific Reports, 5:10934; doi:10.1038/srep10934.

2014

132. Bernard PB, Castano AM, Bayer KU and Benke TA  (2014)  Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures.  Neuropharmacol., 84:1-12.

131.  Bhouri M, Farrow PA, Motee A, Yan X, Battaglia G, Di Menna L, Riozzi B, Nicoletti F, Fitzjohn SM and Bashir ZI  (2014)  mGlu1 Receptor-Induced LTD of NMDA Receptor Transmission Selectively at Schaffer Collateral-CA1 Synapses Mediates Metaplasticity.  J. Neuroscience, 34(36):12223–12229.

130.  Choi J-H, Park P, Baek GC, Sim SE, Kang SJJ, Lee Y, Ahn S-H, Lim C-S, Lee Y-S, Collingridge GL and Kaang B-K  (2014)  Effects of PI3Kγ overexpression in the hippocampus on synaptic plasticity and spatial learning,  Molecular Brain, 7:78.

129. Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AMM, Popoli P and Domenici MR  (2014)  Cocaine-Induced Changes of Synaptic Transmission in the Striatum are Modulated by Adenosine A2A Receptors and Involve the Tyrosine Phosphatase STEP.  Neuropsychopharmacology, 39, 569–578.

128. Clarke VRJ, Molchanova SM, Hirvonen T, Taira T and Lauri SE (2014) Activity-Dependent Upregulation of Presynaptic Kainate Receptors at Immature CA3–CA1 Synapses. J. Neurosci., 34:16902-16916; doi: 10.1523/JNEUROSCI.1842-14.2014.

127.  Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu G-Q, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL and Mucke L  (2014)  Life Extension Factor Klotho Enhances Cognition.  Cell Reports, 7:1065-1076.

126.  Eom T, Muslimov IA, Tsokas P, Berardi V, Zhong J, Sacktor TC and Tiedge H (2014) Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control.  J. Cell Biology, 207:237-252; doi: 10.1083/jcb.201401005.

124. Félix-Oliveira A, Dias RB, Colino-Oliveira M, Rombo DM and Sebastião AM  (2014)  Homeostatic plasticity induced by brief activity deprivation enhances long-term potentiation in the mature rat hippocampus. 

123.  Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE and Mucke L  (2014)  Tau Reduction Prevents Disease in a Mouse Model of Dravet Syndrome.  Ann. Neurology, DOI: 10.1002/ana.24230.

122. Jerónimo-Santos A, Batalha VL, Müller CE, Baqi Y, Sebastião AM, Lopes LV and Diógenes MJ  (2014)  Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.  Neuropharmacology, 83:99-106.

121. Jerónimo-Santos A, Vaz SA, Parreira S, Rapaz-Lérias S, Caetano AP, Buée-Scherrer V, Castrén E, Valente CA, Blum D, Sebastião AM and Diógenes MJ  (2014)  Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain.  Cerebral Cortex, doi:10.1093/cercor/bhu105.

120. Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A and Cho K  (2014)  Microtubule-associated protein tau is essential for long-term depression in the hippocampus.  Phil. Trans. R. Soc. B, 369:20130144, http://dx.doi.org/10.1098/rstb.2013.0144,

119.  Kumar M, Csaba1 Z, Peineau S, Srivastava1 R, Rasika S, Mani S, Gressens P and El Ghouzzi V (2014) Endogenous cerebellar neurogenesis in adult mice with progressive ataxia. Annals of Clinical and Translational Neurology, 1:968–981; DOI: 10.1002/acn3.137

118.  Lee HS, Ghettia A, Pinto-Duarte A, Wang X, Dziewczapolskia G, Galimi F, Huitron-Resendiz S, Piña-Crespo JC, Roberts AJ, Verma IM, Sejnowski TJ and Heinemann SF  (2014)  Astrocytes contribute to gamma oscillations and recognition memory.  PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1410893111.

116.  Lucantonio F, Takahashi YK, Hoffman AF, Chang CY, Bali-Chaudhary S, Shaham Y, Lupica CR and Schoenbaum G  (2014)  Orbitofrontal activation restores insight lost after cocaine use. Nature Neuroscience, 17:1092-1099, doi:10.1038/nn.3763.

115. Luchkina NV, Huupponen J, Clarke VRJ, Coleman SK, Keinänen K, Taira T and Lauri SE  (2014)  Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors.  PNAS, 111:4321-4326. 

114. Mango D, Barbato G, Piccirilli S, Panicoa MB, Feligioni M, Schepisi C, Graziani M, Porrini V, Benarese M, Lanzillotta A, Pizzi M, Pieraccini S, Sironi M, Blandini F, Nicoletti F, Mercuri MB, Imbimboi BP and Nisticò R  (2014)  Electrophysiological and metabolic effects of CHF5074 in thehippocampus: Protection against in vitro ischemia.  Pharmacological Research, 81:83–90.

113.  Mondal S, Sengupta T, Pradhan S, Hansda RN, Mandal PS, Tiwari R and Mukhopadhayay SK  (2014)  Impaired learning and memory after a week long exposure of acetamiprid in adult rats. Adv. Anim. Vet. Sci. 2:543-548. DOI | http://dx.doi.org/10.14737/journal.aavs/2014/2.10.543.548

112. Park P, Volianskis A, Sanderson TM, Bortolotto ZA, Jane DE, Zhuo M, Kaang B-K and Collingridge GL  (2014)  NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Phil. Trans. R. Soc. B, 369:20130131. http://dx.doi.org/10.1098/rstb.2013.0131

110.  Qi J, Zhang S, Wang H-L, Wang H, de Jesus Aceves Buendia J, Hoffman AF, Lupica CR, Seal RP and Morales M (2014) A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons. Nature Communications, 5:5390; doi:10.1038/ncomms6390.

109. Ribeiro PO, Tome AR, Silva HB, Cunha RA and Antunes LM  (2014)  Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.  Brain Res., 1560:10–17.

108. Rodrigues TM, Jerónimo-Santos A, Sebastião AM and Diógenes MJ  (2014)  Adenosine A2A Receptors as novel upstream regulators of BDNFmediated attenuation of hippocampal Long-Term Depression (LTD).  Neuropharmacol., 79:389-398.

107.  Root DH, Mejias-Aponte CA, Zhang S, Wang H-L, Hoffman AF, Lupica CR and Morales M (2014) Single rodent mesohabenular axons release glutamate and GABA. Nature Neuroscience, 17:1543–1551; doi:10.1038/nn.3823.

106. Tong LM, Djukic B, Arnold C, Gillespie AK, Yoon SY, Wang MM, Zhang O, Knoferle J, Rubenstein JLR, Alvarez-Buylla A, and Huang Y  (2014)  Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A Accumulation.  J. Neurosci., 34:9506-9515.

  1. 105. Wallach J, Kavanagh PV, McLaughlin G, Morris N, Power JD, Elliott SP, Mercier MS, Lodge D, Morris H, Dempster NM and Brandt SD  (2014)  Preparation and characterization of the ‘research chemical’ diphenidine, its pyrrolidine analogue, and their 2,2-diphenylethyl isomers.  Drug Testing and Analysis, DOI: 10.1002/dta.1689.

2013

104.  Bernard PB, Castano AM, O’Leary H, Simpson K, Browning MD and Benke TA  (2013)  Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.  Neurobiology of Disease, 59:1–17, doi:10.1016/j.nbd.2013.06.013.

103. Cho T, Ryu JK, Taghibiglou C, Ge Y, Chan AW, Liu L, Lu J, McLarnon JG and  Wang YT  (2013)  Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells.  PLoS ONE 8(10): e76860. doi:10.1371/journal.pone.0076860.

102. Crabtree JW, Lodge D, Bashir ZI and Isaac JTR (2013)  GABAA, NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus.  Eur. J. Neurosci., 37:850–859.

101. Doherty GH, Beccano-Kelly D, Du Yanc S, Gunn-Moorea FJ and Harvey J  (2013)  Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β. Neurobiology of Aging 34:226–237.

100. Felici R, Lapucci A, Ramazzotti M and Chiarugi A  (2013)  Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria. PLoS ONE 8(10):e76938, doi:10.1371/journal.pone.0076938

99. Good CH, Wang H, Chen Y-H, Mejias-Aponte CA, Hoffman AF and Lupica CR  (2013)  Dopamine D4 Receptor Excitation of Lateral Habenula Neurons via Multiple Cellular Mechanisms.  J. Neurosci., 33:16853–16864.

98.  González-Sepúlveda M, Rosell S, Hoffmann HM, del Mar Castillo-Ruiz M, Mignon V, Moreno-Delgado D, Vignes M, Díaz J, Sabriá J, Ortiz J  (2013)  Cellular distribution of the histamine H3 receptor in the basal ganglia: Functional modulation of dopamine and glutamate neurotransmission.  Basal Ganglia, 3:109-121.

  • 97. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z and Lodge D  (2013)  Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.  Neuropharmacol., 66:114-121.

96.  Huang Y, Hu Z, Liu G, Zhou W and Zhang Y  (2013)  Cytokines induced by long-term potentiation (LTP) recording: A potential explanation for the lack of correspondence between learning/memory performance and LTP.  Neuroscience, 231:432–443.

95. Latour A, Grintal B, Champeil-Potokar G, Hennebelle M, Lavialle M, Dutar P, Potier B, Billard J-M, Vancassel S, Denis I  (2013)  Omega-3 fatty acids deficiency aggravates glutamatergic synapse and astroglial aging in the rat hippocampal CA1.  Aging Cell, 12:76–84.

94. Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA and Collingridge GL  (2013)  Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.  Neuropharmacol., 74:135–146.

93. Lucas SJ, Bortolotto ZA, Collingridge GL and Lodge D  (2013)  Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala. Neuropharmacol., 66:196–201.

92. Luchkina NV, Sallert M, Clarke VRJ, Taira T and Lauri SE  (2013)  Mechanisms underlying induction of LTP-associated changes in short-term dynamics of transmission at immature synapses.  Neuropharmacol., 67:494-502.

91. Martin S, Zekri L, Metz A, Maurice T, Chebli H, Vignes M and Tazi j  (2013)  Deficiency of G3BP1, the stress granules assembly factor, results in abnormal synaptic plasticity and calcium homeostasis in neurons.  J. Neurochem., 125:175–184.

90. Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA  (2013)  Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus. Neuropharmacol., 67:294–303.

89. Panaccione I, King R, Molinaro G, Riozzi B, Battaglia G, Nicoletti F and Bashir ZI  (2013)  Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex.  Neuropharmacol., 66:143–150.

88. Pettem KL, Yokomaku D, Luo L, Linhoff MW, Prasad T, Connor SA, Siddiqui TJ, Kawabe H, Chen F, Zhang L, Rudenko G, Wang YT, Brose N and Craig AM  (2013)  The Specific a-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development.  Neuron, 80:113–128.

87. Reich CG, Mihalik GR, Iskander AN, Seckler JC AND Weiss MS  (2013)  Adolescent chronic mild stress alters hippocampal CB1 receptor-mediated excitatory neurotransmission and plasticity.  Neuroscience, 253:444-454.

86. Rocca DL, Amici M, Antoniou A, Suarez EB, Halemani N, Murk K, McGarvey J, Jaafari N, Mellor JR, Collingridge GL and Hanley JG  (2013)  The Small GTPase Arf1 Modulates Arp2/3-Mediated Actin Polymerization via PICK1 to Regulate Synaptic Plasticity.  Neuron, 79:293–307.

85. Rosenberg D, Artoul S, Segal AC, Kolodney G, Radzishevsky I, Dikopoltsev E, Foltyn VN, Inoue R, Mori H, Billard J-M, and Wolosker H  (2013)  Neuronal d-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity  J. Neurosci., 33:3533-3544.

84. Scattoni ML, Martire A, Cartocci G, Ferrante A and Ricceri L  (2013)  Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism,  Behavioural Brain Research, dx.doi.org/10.1016/j.bbr.2012.12.028.

83. Siddiqui TJ, Tari PK, Connor SA, Zhang P, Dobie FA, She K, Kawabe H, Wang YT, Brose N and Craig AM  (2013)  An LRRTM4-HSPG Complex Mediates Excitatory Synapse Development on Dentate Gyrus Granule Cells.  Neuron, 79:680–695.

82. Srivastava R, Kumar M, Peineau S, Csaba Z, Mani S, Gressems P and El Ghouzzi V  (2013)  Conditional Induction of Math1 Specifies Embryonic Stem Cells to Cerebellar Granule Neuron Lineage and Promotes Differentiation into Mature Granule Neurons.  Stem Cells, 31:652–665.

81. Sonner PM and Ladle DR  (2013)  Early postnatal development of GABAergic presynaptic inhibition of Ia proprioceptive afferent connections in mouse spinal cord.  J. Neurophysiol. 109:2118-2128.

80. Tamagnini F, Barker GRI, Warburton CE, Burattini C, Aicardi G and Bashir Z  (2013)  Nitric oxide-dependent LTD but not endocannabinoid-LTP is crucial for visual recognition memory. J. Physiol., 591:3963-3979, 10.1113/jphysiol.2013.254862.

79. Titus DJ, Furones C, Kang Y and Atkins CM  (2013)  Age-Dependent Alterations in cAMP Signaling Contribute to Synaptic Plasticity Deficits Following Traumatic Brain Injury. Neuroscience, 231:182–194. doi:10.1016/j.neuroscience.2012.12.002.

78. Titus DJ, Sakurai A, Kang Y, Furones C, Jergova S, Santos R, Sick TJ and Atkins CM  (2013)  Phosphodiesterase inhibition rescues chronic cognitive deficits induced by traumatic brain injury.  J. Neurosci., 33:5216-5226.

77. Villers A and Ris L  (2013)  Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation.  JoVE (Journal of Visualized Experiments), doi: 10.3791/50483.

76.  Whitehead G, Jo J, Hogg EL, Piers T, Kim D-H, Seaton G, Seok H, Bru-Mercier G, Son GH, Regan P, Hildebrandt L, Waite E, Kim B-C, Kerrigan TL, Kim K, Whitcomb DJ, Collingridge GL, Lightman SL and Cho K  (2013)  Acute stress causes rapid synaptic insertion of Ca2+-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus.  Brain, 136:3753–3765.

2012

  • 75. Ceolin L, Bortolotto ZA, Bannister N, Collingridge GL, Lodge D and Volianskis A  (2012)  A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus.  Neurochemistry International, 61:517-522.

74. Clarke VRJ, Collingridge GL, Lauri SE and Taira T  (2012)  Synaptic kainate receptors in CA1 interneurons gate the threshold of theta-frequency-induced long-term potentiation.  J. Neurosci., 32:18215-18226.

73. Colotta V, Lenzi O, Catarzi D, Varano F, Squarcialupi L, Costagli C, Galli A, Ghelardini C, Pugliese AM, Maraula G, Coppi E, Pellegrini-Giampietro DE, Pedata F, Sabbadin D and Moro S  (2012)  3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: Molecular modeling and pharmacological studies.  Eur. J. Med. Chem., 54:470–482.

72. Dias RB, Ribeiro JA and Sebastião AM  (2012)  Enhancement of AMPA currents and GluR1 membrane expression through PKA-coupled adenosine A2A receptors.  Hippocampus, 22:276–291.

71. Diógenes MJ, Dias RB, Rombo DM, Miranda HV, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LMA, Castanho MARB, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV and Outeiro TF  (2012)  Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.  J. Neurosci., 32:11750-11762.

70. Freret T, Billard J-M, Schumann-Bard P, Dutar P, Dauphin F, Boulouard M and Bouet V  (2012)  Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.  Neurobiology of Aging, 33:1005.e1–1005.e10.

69. Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G?, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnar E, Monaghan DT, Jane DE (2012) Piperazine-2,3-dicarboxylic Acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors. J. Med. Chem., 55:327-341.

68. Haxaire C, Turpin FR, Potier B, Kervern M, Sinet P-M, Barbane G, Mothet J-P, Dutar P, Billard J-M (2012) Reversal of age-related oxidative stress prevents hippocampal synaptic plasticity deficits by protecting d-serine-dependent NMDA receptor activation. Aging Cell, 11:336–344.

67. Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TMK, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD and Bahn S  (2012) The Methylazoxymethanol Acetate (MAM-E17) Rat Model: Molecular and Functional Effects in the Hippocampus.  Neuropsychopharmacology, 37:364–377

66. Huang Y, Yang S, Hu Z-Y, Liu G, Zhou W-X and Zhang Y-X  (2012)  A new approach to location of the dentate gyrus and perforant path in rats/mice by landmarks on the skull  Acta Neurobiol. Exp., 468–472.

65. Huang Y, Zhang H, Yang S, Qiao H, Zhou W and Zhang Y  (2012)  Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDCCs) and promoting N-methyl-d-aspartate receptor (NMDA) receptors. J. Ethnopharm., 140:384–390.

64.  Huupponen, J, Molchanova SM, Lauri SE and Taira T  (2012)  Ongoing intrinsic synchronous activity is required for the functional maturation of CA3-CA1 glutamatergic synapses.  Cerebral Cortex, doi: 10.1093/cercor/bhs262.

63. Jain S, Yoon SY, Zhu L, Brodbeck J, Dai J, Walker D, Huang Y  (2012)  Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development.  PLoS ONE 7(9): e46340. doi:10.1371/journal.pone.0046340.

62. Kaindl AM, Degos V, Peineau S, Gouadon E, Chhor V, Loron G, Le Charpentier T, Josserand J, Ali C, Vivien D, Collingridge GL, Lombet A, Issa L, Rene F, Loeffler JP, Kavelaars A, Verney C, Mantz J and Gressens P  (2012)  Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain.  Ann. Neurology, 72:536–549.

61. Kratzer S, Mattusch C, Kochs E, Eder M, Haseneder R and Rammes Gerhard  (2012)  Xenon Attenuates Hippocampal Long-term Potentiation by Diminishing Synaptic and Extrasynaptic N-methyl-D-aspartate Receptor Currents. Anesthesiology, 116:673-682.

  • 60. Lucas SJ, Bortolotto ZA, Collingridge GL and Lodge D  (2012)  Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.  Neuropharmacology, in press.

59. Luchkina NV, Sallert M, Clarke VRJ, Taira T and Lauri SE  (2012)  Mechanisms underlying induction of LTP-associated changes in short-term dynamics of transmission at immature synapses.  Neuropharmacol., 67:494-502.

58. Muzzi M, Blasi F, Masi A, Coppi E, Traini C, Felici R, Pittelli M, Cavone L, Pugliese AM, Moroni F and Chiarugi A  (2012)  Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.  J. Cerebral Blood Flow & Metabolism, doi:10.1038/jcbfm.2012.157.

57. Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi S-L, Sim S-E, Bradley C, Lee K, Zhuo M, Kaang B-K, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K and Collingridge GL  (2012)  The JAK/STAT Pathway Is Involved in Synaptic Plascity.  Neuron, 73:374–390.

56. Nuritova F and Frenguelli BG  (2012)  Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors.  Neurosci., 222:159-172.

  • 55. Panaccione I, King R, Molinaro G, Riozzi B, Battaglia G, Nicoletti F and Bashir ZI  (2012) Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex.  Neuropharmacology, in press.

54. Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E and Vivien  (2012)  Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.  Cell Death & Differentiation, 19:1983-1991.

53. Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA and Smolders I  (2012)  Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents. Neurotherapeutics, 9:658-672.

52. Regnier V, Billard J-M, Gupta S, Potier B, Woerner S, Paly E, Aurelie Ledru, David S, Luilier S, Bizot J-C, Vacano G, Kraus JP, Patterson D, Kruger WD, Delabar JM, London J (2012) Brain Phenotype of Transgenic Mice Overexpressing Cystathionine b-Synthase. PLOS ONE, 7:e29056.

51. Romberg C, McTighe SM, Heath CJ, Whitcomb DJ, Cho K, Bussey TJ and Saksida LM  (2012)  False recognition in a mouse model of Alzheimer’s disease: rescue with sensory restriction and memantine.  Brain, doi:10.1093/brain/aws074.

50.  Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ and Mucke L  (2014)  Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model.  Proc. Nat Acad Sci., 109:2895-2903.

49. Sanderson TM, Cotel MC, O’Neill MJ, Tricklebank MD, Collingridge GL and Sher E  (2012)  Alterations in hippocampal excitability, synaptic transmission and synaptic plasticity in a neurodevelopmental model of schizophrenia.  Neuropharmacology, 62:1349-1358.

48. Scott   HL, Tamagnini F, Narduzzo KE, Howarth JL, Lee YB, Wong LF, Brown MW, Warburton EC, Bashir ZI and Uney JB  (2012)  MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.  Eur. J Neurosci., 36: 2941–2948.

47. Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA  (2012)  Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.  Neurochemistry International, 61:482-489.

46. Shonesy BC, Thiruchelvam K, Parameshwaran K, Rahman EA, Karuppagounder SS, Huggins KW, Pinkert CA, Amina R,  Dhanasekaran M and Suppiramaniam V  (2012)  Central insulin resistance and synaptic dysfunction in intracerebroventricular-streptozotocin injected rodents.  Neurobiology of Aging, 33:430.e5– 430.e18.

45. Srivastava R, Kumar M, Peineau S, Csaba Z, Mani S, Gressens P, El Ghouzzi V  (2012)  Conditional induction of Math1 specifies embryonic stem cells to cerebellar granule neuron lineage and promotes differentiation into mature granule neurons.  Stem Cells,  31:652–665.

44. Supcun B, Ghadiri MK, Zeraati M, Stummer W, Speckmann EJ, Gorji A  (2012)  The effects of tetanic stimulation on plasticity of remote synapses in the hippocampus-perirhinal cortex-amygdala network.  Synapse, 66:965-974.

43. Titus DJ, Furones C, Kang Y,  Atkins CM  (2013)  Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.  Neuroscience, 231:182-194.

42. Villers A, Godaux E, Ris L (2012) Long-Lasting LTP Requires Neither Repeated Trains for Its Induction Nor Protein Synthesis for Its Development. PLoS ONE 7(7): e40823. doi:10.1371/journal.pone.0040823

2011

41. Bartlett TE, Lu J and Wang YT  (2011)  Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression.  Mol. Brain, 4:41.

40. Bouet V, Freret T, Dutar P, Billard J-M, Boulouard M (2011) Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals. Mechanisms of Ageing and Development, 132:240-248.

39. Caruana DA, Warburton ED, Bashir ZI (2011) Induction of Activity-Dependent LTD Requires Muscarinic Receptor Activation in Medial Prefrontal Cortex. J. Neurosci., 31:18464-18478.

38. Ceolin L, Kantamneni S, Barker GRI, Hanna L, Murray L, Warburton EC, Robinson ESJ, Monn JA, Fitzjohn SM, Collingridge GL,  Bortolotto ZA and Lodge D  (2011)  Study of Novel Selective mGlu2 Agonist in the Temporo-Ammonic Input to CA1 Neurons Reveals Reduced mGlu2 Receptor Expression in a Wistar Substrain with an Anxiety-Like Phenotype.  J. Neurosci., 31:6721– 6731.

37. Errico F, Nisticò R, Napolitano F, Mazzola C, Astone D, Pisapia T, Giustizieri M, D’Aniello A, Mercuri NB, Usiello A  (2011)  Increased d-aspartate brain content rescues hippocampal age-related synaptic plasticity deterioration of mice.  Neurobiol. Aging, 32:2229–2243.

36. Escobar M , Crouzin N , Cavalier M , Quentin J , Roussel J , Lanté F , Batista-Novais AR , Cohen-Solal C , De Jesus Ferreira M-C , Guiramand J , Barbanel G and Vignes M  (2011)  Early, Time-Dependent Disturbances of Hippocampal Synaptic Transmission and Plasticity After In Utero Immune Challenge.  Biol. Psychiatry, 70:992–999.

35. Gan J, Greenwood SM, Cobb SR and Bushell TJ  (2011)  Indirect modulation of neuronal excitability and synaptic transmission in the hippocampus by activation of proteinase-activated receptor-2.  Brit. J. Pharmacol, 163:984-994.

34. Kim J-I, Lee H-R, Sim S, Baek J, Yu N-K, Choi J-H, Ko H-G, Lee Y-S, Park S-W, Kwak C, Ahn S-J, Choi SY, Kim H, Kim K-H,  Backx PH, Bradley CA, Kim E, Jang D-J, Lee K, Kim SJ, Zhuo M, Collingridge GL and Kaang B-K  (2011)  PI3Kg is required for NMDA receptor–dependent long-term depression and behavioral flexibility.  Nature Neuroscience, 14:1447–1454.

33.  Koch S, Molchanova SM, Wright AK, Edwards A, Cooper JD, Taira T, Gillingwater TH, Tyyne J (2011) Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis. J. Neuropathology & Experimental Neurology, 70:1089-1096.

32. Min J-A, Lee H-R, Kim J-I, Jub A, Kim D-J, Kaang B-K  (2011)  Impairment of long-term potentiation in the hippocampus ofalcohol-treated OLETF rats.  Neuroscience Letters, 500:52-56.

31. Moult PR and Harvey J  (2011)  NMDA receptor subunit composition determines the polarity of leptin-induced synaptic plasticity.  Neuropharmacology, 61:924-936.

30. Sanderson TM, Collingridge GL and Fitzjohn SM  (2011)  Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs  Molecular Brain, 4:30.

29. Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH and Craig AM  (2011)  Postsynaptic TrkC and Presynaptic PTPs Function as a Bidirectional Excitatory Synaptic Organizing Complex.  Neuron, 69, 287–303.

28. Weng S-M, McLeod F, Bailey MES and Cobb SR (2011)  Synaptic Plasticity Deficits in an Experimental Model of Rett Syndrome: Long-Term Potentiation Saturation and its Pharmacological Reversal.  Neuroscience 180:314–321.

2010

27. Armogida M, Giustizieri M, Zona C, Piccirilli S, Nisticò R, Mercuri NB  (2010)  N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: An in vitro electrophysiological study.  Synapse, 64:161-168.

26. Potier B, Billard J-M, Rivière S, Sinet P-M, Denis I, Champeil-Potokar G, Grintal B, Jouvenceau A, Kollen M, Dutar P  (2010)  Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats.  Aging Cell, 9:722–735.

25. Hoffman AF, Laaris N, Kawamura M, Masino SA, Lupica CR  (2010)  Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A1 Receptors.  J. Neurosci., 30:545-555.

24. Jo J, Son GH, Winters BL, Kim MJ, Whitcomb DJ, Dickenson BA, Lee Y-B, Futai K, Amici M, Sheng M, Collingridge GL and Cho K  (2010)  Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.  Nature, 13:1216–1224.

23. Kamsler A, McHugh TJ, Gerber D, Huang SY, Tonegawa S  (2010)  Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus.  PNAS, 107:1618-1623.

22. Lagostena L, Rosato-Siri M, Onofrio M, Brandi R, Arisi I, Capsoni S, Franzot J, Cattaneo A, Cherubini E  (2010)  In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction.  J. Neurosci., 30:885-893.

21. Moult PR, Cross A, Santos SD, Carvalho A-L, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J  (2010)  Leptin Regulates AMPA Receptor Trafficking via PTEN Inhibition.  J. Neurosci., 30:4088-4101.

20. Villers A, Godaux E, Ris L  (2010)  Late phase of L-LTP elicited in isolated CA1 dendrites cannot be transferred by synaptic capture.  NeuroReport, 21:210-215.

2009

19. Dargan SL, Clarke VRJ, Alushin GM, Sherwood JL, Nistico R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL  (2009)  ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function.  Neuropharmacol., 56:121-130.

18. Hong I, Song B, Lee S, Kim J, Kim J, Choi S  (2009)  Extinction of cued fear memory involves a distinct form of depotentiation at cortical input synapses onto the lateral amygdala.  Eur. J. Neurosci., 30:2089-2099.

17. Karlen A, Karlsson TE, Mattsson A, Lundstromer K, Codeluppi S, Pham TM, Backman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, Brene S, Olson L  (2009)  Nogo receptor 1 regulates formation of lasting memories.  PNAS, 106:20476-20481.

16. Kim J, Park S, Lee S and Choi S  (2009)  Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis.  Neuroreport, 20:517-520.

15. Lagostena L, Danober L, Challal S, Lestage P,  Mocaër E, Trocmé-Thibierge C, Cherubini E  (2009)  Modulatory effects of S 38232, a non α-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus.  Neuropharmacol., 58:806-815.

14. Martella G, Tassone A, Sciamanna G, Platania P, Cuomo D, Viscomi MT, Bonsi P, Cacci E, Biagioni S, Usiello A, Bernardi G, Sharma N, Standaert DG, Pisani A  (2009)  Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine.  Brain, 132:2336-2349.

13. Omrani A, Melone M, Bellesi M, Safiulina V, Aida T, Tanaka K, Cherubini E, Conti F  (2009)  Up-regulation of GLT-1 severely impairs LTD at mossy fibre-CA3 synapses.  J. Physiol., 587:4575-4587.

12. Peineau S, Nicolas CS, Bortolotto ZA, Bhat RV, Jonathan Ryves W, Harwood AJ, Dournaud P, Fitzjohn SM, Collingridge GL  (2009)  A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.  Mol. Brain, 2:22 (10 pages).

11. Ris L, Villers A, Godaux E  (2009)  Synaptic capture-mediated long-lasting long-term potentiation is strongly dependent on mRNA translation.  NeuroReport, 20:1572-1576.

10. Sallert M, Rantamaki T, Vesikansa A, Anthoni H, Harju K, Yli-Kauhaluoma J, Taira T, Castren E, Lauri SE  (2009)  Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1 Synapses by Downregulating Tonic Activation of Presynaptic Kainate Receptors.  J. Neurosci., 29:11294-11303.

9. Seoane A, Massey PV, Keen H, Bashir ZI, Brown MW  (2009)  L-Type Voltage-Dependent Calcium Channel Antagonists Impair Perirhinal Long-Term Recognition Memory and Plasticity Processes.  J. Neurosci., 29:9534-9544.

8. Zadran S, Qin Q, Bi X, Zadran H, Kim Y, Foy MR, Thompson R, Baudry M  (2009)  17-β-Estradiol increases neuronal excitability through MAP kinase-induced calpain activation PNAS, 106:21936-21941.

2008

7. Fernandes CC, Pinto-Duarte A, Ribeiro JA, and Sebastiao AM  (2008)  Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.  J. Neurosci., 28:5611–5618.

6. Jo J, Heon S, Kim MJ, Son GH, Park Y, Henley JM, Weiss JL, Sheng M, Collingridge GL and Cho K  (2008)  Metabotropic Glutamate Receptor-Mediated LTD Involves Two Interacting Ca2+ Sensors, NCS-1 and PICK1.  Neuron, 60:1095-1111.

5. Lagostena L, Trocme-Thibierge C, Morain P and Cherubini E  (2008)  The partial a7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus.  Neuropharmacol., 54:676-685.

4. Giustizieri M, Armogida M, Berretta N, Federici M, Piccirilli S, Mercuri NB, Nistico R (2008)  Differential effect of carbamazepine and oxcarbazepine on excitatory synaptic transmission in rat hippocampus. Synapse 62:783–789.

3. Biber K, Pinto-Duarte A, Wittendorp MC, Dolga AM, Fernandes CC, Von Frijtag Drabbe Kunzel J, Keijser JN, de Vries R, Ijzerman AP, Ribeiro JA, Eisel U, Sebastião AM and Boddeke HWGM  (2008)  Interleukin-6 upregulates neuronal Adenosine A1 receptors: Implications for neuromodulation and neuroprotection.     Neuropsychopharmacol., 33:2237-2250.

2007

2. Lanté F, Meunier J, Guiramand J, Maurice T, Cavalier M, de Jesus Ferreira MC, Aimar R, Vignes M and Barbanel G (2007)  Neurodevelopmental damage after prenatal infection: Role of oxidative stress in the fetal brain.  Free Radical Biology and Medicine, 42:1231–1245.

1.  Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bortolotto ZA, Wang YT, Collingridge GL  (2007)  UP inhibits LTD in the hippocampus via regulation of GSK3 beta. Neuron, 53:703-717.

 

 

LTP Program

The LTP Program has been used in at least 355 publications.  

2015

355.  Ahmed Z and Wieraszko A (2015) Pulsed magnetic stimulation modifies amplitude of action potentials in vitro via ionic channels-dependent mechanism. Bioelectromagnetics, 36:386–397, DOI: 10.1002/bem.21917.

354.  Gonçalves FQ, Pires J, Pliassova A, Beleza R, Lemos C, Marques JM, Rodrigues RJ, Canas PM, Köfalvi A, Cunha RA and Rial D  (2015)  Adenosine A2b receptors control A1 receptor-mediated inhibition of synaptic transmission in the mouse hippocampus.  Eur. J. Neurosci., 41:878–888; DOI: 10.1111/ejn.12851.

353.  Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Dami TE, Berti A, Stefani M and Casamenti F (2015) Oleuropein aglycone protects against pyroglutamylated-3 amyloid-ß toxicity: biochemical, epigenetic and functional correlates. Neurobiology of Aging, 36:648–663; doi:10.1016/j.neurobiolaging.2014.08.029.

352.  Li W, Silva HB, Real J, Wang Y-M, Rial D, Li P, Payen M-P, Zhou Y, Muller CE, Tomé AR, Cunha RA and Chen J-F (2015) Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models. Neurobiology of Disease, 79:70–80; doi:10.1016/j.nbd.2015.03.030.

351.  Pál I, Kardos J, Dobolyi A and Héja L (2015) Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. Molecular Brain, 8:35; DOI 10.1186/s13041-015-0127-9.

350.  Rammes G, Gravius A, Ruitenberg M, Wegener N, Chambon C, Sroka-Saidi K, Jeggo R, Staniaszek L, Spanswick D, O'Hare E, Palmer P, Kim E-M, Bywalez W, Egger V and Parsons CG (2015) MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice. Neuropharmacology, 92:170–182.

349.  Santos AR, Mele M, Vaz SH, Kellermayer B, Grimaldi M, Colino-Oliveira M, Rombo DM, Comprido D, Sebastião AM and Duarte CB (2015) Differential Role of the Proteasome in the Early and Late Phases of BDNF-Induced Facilitation of LTP. J. Neurosci., 35:3319-3329; doi: 10.1523/JNEUROSCI.4521-14.2015.

2014

348. Assaife-Lopes N, Sousa VC, Pereira DB, Ribeiro JA and Sebastião AM  (2014)  Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity.  Purinergic Signalling, 10:251–267.

 347.  Bhagya V, Srikumar BN, Raju TR and Shankaranarayana Rao BS  (2014)  The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression.  J. Neuroscience Research, DOI: 10.1002/jnr.23473.

346.  Cunha-Reis D, de Fatima Aidil-Carvalho M and Ribeiro JA  (2014)  Endogenous Inhibition of Hippocampal LTD and Depotentiation by Vasoactive Intestinal Peptide VPAC1 Receptors.  Hippocampus, DOI: 10.1002/hipo.22316.

345.  Ferrante A, Martire A, Pepponi R, Varani K, Vincenzi F, Ferraroc L, Beggiato S, Tebano MT and Popoli P  (2014)  Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease.  Neurobiology of Disease, 71:193–204.

344.  Fezza F, Marrone MC, Avvisati R, Di Tommaso M, Lanuti M, Rapino C, Mercuri NB, Maccarrone M and Marinelli S  (2014) Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.  Molecular and Cellular Neuroscience 62:1–9.

343.  Jiang Y, Liu Y, Zhu C, Ma X, Ma L, Zhou L, Huang Q, Cen L, Pi R and Chen X (2015) Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiology of Learning and Memory, 121:20–29, doi:10.1016/j.nlm.2015.03.003.

342.  Laing M and Bashir ZI  (2014)  β-Adrenoceptors and synaptic plasticity in the perirhinal cortex.  Neuroscience, 273:163-173.

341. Liu Q-Y, Wang C-Y, Cai Z-L, Xu S-T, Liu W-X, Xiao P and Li C-H  (2014)  Effects of intrahippocampal GABAB receptor antagonist treatment on the behavioral long-term potentiation and Y-maze learning performance.  Neurobiology of Learning and Memory, 114:26–31.

340. Luccarini I, Grossi C, Rigacci S, Coppi E, Pugliese AM, Pantano D, la Marca G, Dami TE, Berti A, Stefani M, Casamenti F  (2014)  Oleuropein aglycone protects against pyroglutamylated-3 Aß toxicity: biochemical, epigenetic and functional correlates.  Neurobiology of Aging, DOI: 10.1016/j.neurobiolaging.2014.08.029.

339.  Maraula G, Lana D, Coppi E, Gentile F, Mello T, Melani A, Galli A, Giovannini MG, Pedata F and Pugliese AM (2014) The Selective Antagonism of P2X7 and P2Y1 Receptors Prevents Synaptic Failure and Affects Cell Proliferation Induced by Oxygen and Glucose Deprivation in Rat Dentate Gyrus. PLOS|One, DOI: 10.1371/journal.pone.0115273.

338.  Nedden S, Doney AS and Frenguelli BG  (2014)  Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells.  J. Neurochem., 128:111-124.

337.  Rial D, Castro AA, Machado N, Garção P, Gonçalves FQ, Silva HB, Tomé AR, Köfalvi A, Corti O, Raisman-Vozari R, Cunha RA and Prediger RD (2014) Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease. PLOS|One, DOI: 10.1371/journal.pone.0114216.

336.  Ribeiro PO, Tome´ AR, Silva HB, Cunha RA and Antunes LM  (2014)  Clinically relevant concentrations of ketamine mainly affect long-term potentiation rather than basal excitatory synaptic transmission and do not change paired-pulse facilitation in mouse hippocampal slices.  Brain Research, 1560:10–17.

 335.  Sousa VC, Vital J, Costenla AR, Batalha VL, Sebastião AM, Ribeiro JA and Lopes  lv  (2014)  Maternal separation impairs long term-potentiation in CA1-CA3 synapses and hippocampal-dependent memory in old rats. Neurobiology of Aging, 35:1680-1685.

2013

334. Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean M-E, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D  (2013)  NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.  Aging Cell, 12:11–23.

333.  Ferreira AC, Pinto V, Dá Mesquita S, Novais A, Sousa JC, Correia-Neves M, Sousa N, Palha JA and Marques F  (2014)  Lipocalin-2 is involved in emotional behaviors and cognitive function.  Front. Cell Neurosci., 7:122.

332. Haseneder R, Starker L, Berkmann J, Kellermann K, Jungwirth B, Blobner M, Eder M, Kochs E and Rammes G (2013) Sevoflurane Anesthesia Improves Cognitive Performance in Mice, but Does Not Influence In Vitro Long-Term Potentation in Hippocampus CA1 Stratum Radiatum. PLoS ONE 8(5): e64732. doi:10.1371/journal.pone.0064732

331. Martire A, Pepponi R, Domenici MR, Ferrante A, Chiodi V, Popoli P  (2013)  BDNF prevents NMDA-induced toxicity in models of Huntington's disease: the effects are genotype specific and adenosine A2A receptor is involved.  J. Neurochem., 125:225-235.

330. Maraula G, Traini C, Mello T, Coppi E, Galli A, Pedata F, Pugliese AM  (2013)  Effects of oxygen and glucose deprivation on synaptic transmission in rat dentate gyrus: Role of A2A adenosine receptors.  Neuropharmacol., 67:511-520.

329. McLeod F, Ganley R, Williams L, Selfridge J, Bird A and Cobb SR  (2012)  Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome.  Neuroscience, 231:195-205.

328. Muzzi M, Coppi E, Pugliese AM and Chiarugi A  (2013)  Anticonvulsant effect of AMP by direct activation of adenosine A1 receptor.  Experimental Neurology, 250:189–193.

327. Pál I, Nyitrai G, Kardos J, Héja L  (2013)  Neuronal and astroglial correlates underlying spatiotemporal intrinsic optical signal in the rat hippocampal slice.  PLoS ONE 8(3): e57694. doi:10.1371/journal.pone.0057694.

326. Remenyi J, van den Bosch MWM, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JSC, Frenguelli BG and Pankratov (2013)  miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity. PLoS ONE 8(4): e62509. doi:10.1371/journal.pone.0062509.

325. Rodi D, Buzzi A, Barbieri M, Zucchini S, Verlengia G, Binaschi A, Regoli D, Boschi A, Ongali B, Couture R, Simonato M  (2013)  Bradykinin B2 Receptors Increase Hippocampal Excitability And Susceptibility To Seizures In Mice.  Neuroscience, dx.doi.org/10.1016/j.neuroscience.2013.06.038.

 324.  Scattonia ML, Martire A, Cartoccia G, Ferrante A and Ricceri L  (2013)  Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism.  Behavioural Brain Research, 251:35–40.

323. Tatini F, Pugliese AM, Traini C, Niccoli S, Maraula G, Dami TE, Mannini B, Scartabelli T, Pedata F, Casamenti F and Chiti F  (2013)  Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N.  Neurobiology of Aging, 34:2100–2109.

322. Uthayathas S, Parameshwaran K, Karuppagounder SS, Ahuja M, Dhanasekaran M, Suppiramaniam V  (2013)  Selective inhibition of phosphodiesterase 5 enhances glutamatergic synaptic plasticity and memory in mice. DOI: 10.1002/syn.21676.

321.  Wang J, Liu Y, Zhou L-J, Wu Y, Li F, Shen K-F, Pang R-P, Wei X-H, Li Y-Y and Liu X-G  (2013)  Magnesium L-threonate Prevents and Restores Memory Deficits Associated with Neuropathic Pain by Inhibition of TNF-α.  Pain Physician, 16:E563-E575.

2012

320.  Chiodi V, Uchigashima M, Beggiato S, Ferrante A, Armida M, Martire A, Potenza RL, Ferraro L, Tanganelli S, Watanabe M, Domenicia MR, Popolia P (2012) Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease. Neurobiology of Disease, 45:983–991.

319.  Damborsky JC, Griffith WH and Winzer-Serhan UH  (2011)  Chronic neonatal nicotine exposure increases excitation in the young adult rat hippocampus in a sex-dependent manner.  Brain Res., 1430:8–17

318. Diógenes MJ, Neves-Tomé R, Fucile S, Martinello K, Scianni M, Theofilas P, Lopatář J, Ribeiro JA, Maggi L, Frenguelli BG, Limatola C, Boison D and Sebastião AM  (2012)  Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.  Cerebral Cortex, doi: 10.1093/cercor/bhs284.

317. Jacob W, Marsch R, Marsicano G, Lutz B and Wotjak CT  (2012)  Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo.  Neurobiology of Learning and Memory, 98:47-55.

316. Kanju PM, Parameshwaran K, Sims-Robinson C, Uthayathas S, Josephson EM, Rajakumar N, Dhanasekaran M, Suppiramaniam V  (2012)  Selective Cholinergic Depletion in Medial Septum Leads to Impaired Long Term Potentiation and Glutamatergic Synaptic Currents in the Hippocampus.  PLoS ONE, 7:e31073.

315. Maggio N and Segal M  (2012)  Cellular Basis of a Rapid Effect of Mineralocorticosteroid Receptors Activation on LTP in Ventral Hippocampal Slices.  Hippocampus, 22:267–275.

314. Park S-W, Jang H-J, Cho K-H, Kim M-J, Yoon SH, and Rhie D-J  (2012)  Developmental Switch of the Serotonergic Role in the Induction of Synpatic Long-term Potentiation in the Rat Visual Cortex.  Korean J Physiol Pharmacol., 16:65–70.

313. Perugini A, Laing M, Berretta N, Aicardi G, Bashir ZI  (2012)  Synaptic plasticity from amygdala to perirhinal cortex: a possible mechanism for emotional enhancement of visual recognition memory?  Eur. J. Neuroscience, 36:2421–2427.

312. Parameshwaran K, Buabeid MA, Karuppagounder SS, Uthayathas S, Thiruchelvam K, Shonesy B, Dityatev A, Escobar MC, Dhanasekaran M and Suppiramaniam V  (2012)  Developmental nicotine exposure induced alterations in behavior and glutamate receptor function in hippocampus.  Cell. Mol. Life Sci., 69:829–841

311.  Purkayastha S, Ford J, Kanjilal B (2012) Clozapine Functions Through the Prefrontal Cortex Serotonin 1A Receptor to Heighten Neuronal Activity via Calmodulin Kinase II?NMDA Receptor Interactions. J. Neurochem., 120:396-407.

310. Zhang H, Etherington L-A, Hafner A-S, Belelli D, Coussen F, Delagrange P, Chaouloff F, Spedding M, Lambert JJ, Choquet D and Groc L  (2012)  Regulation of AMPA receptor surface trafficking and synaptic plasticity by a cognitive enhancer and antidepressant molecule.  Molecular Psychiatry, doi: 10.1038/mp.2012.80.

2011

309. Appleby VJ, Corrêa SAL, Duckworth JK, Nash JE, Noël J, Fitzjohn SM, Collingridge GL and Molnár E  (2011)  LTP in hippocampal neurons is associated with a CaMKII-mediated increase in GluA1 surface expression.  J. Neurochem., 116:530–543.

308. Bhagya V, Srikumar BN, Raju TR and Rao BSS  (2011)  Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression.  Psychopharmacology, 214:477–494.

307. Costenla AR, Diogenes MJ, Canas PM, Rodrigues RJ, Nogueira C, Maroco J, Agostinho PM, Ribeiro JA, Cunha RA and de Mendonca A  (2011)  Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hippocampus upon ageing.  European J. Neurosci., 34:12–21.

306. Diogenes MJ, Costenla AR, Lopes LV, Jeronimo-Santos A, Sousa VC, Fontinha BM, Ribeiro JA and Sebastiao AM  (2011)  Enhancement of LTP in Aged Rats is Dependent on Endogenous BDNF.  Neuropsychopharmacology, 36:1823–1836.

305. Ishikawa Y, Tamura H and Shiosaka S  (2011)  Diversity of neuropsin (KLK8)-dependent synaptic associativity in the hippocampal pyramidal neuron.  J Physiol 589:3559–3573.

304. Lopatár J, Dale N, Frenguelli BG  (2011)  Minor contribution of ATP P2 receptors to electrically-evoked electrographic seizure activity in hippocampal slices: Evidence from purine biosensors and P2 receptor agonists and antagonists. Neuropharmacology, 61:25-34.

303. Maggio N and Segal M  (2011)  Persistent Changes in Ability to Express Long-Term Potentiation/Depression in the Rat Hippocampus After Juvenile/Adult Stress.  Biol. Psychiatry, 69:748–753.

302. Martire A, Tebano MT, Chiodi V, Ferreira SG, Cunha RA, Köfalvi A and Popoli P  (2011)  Pre-synaptic adenosine A2A receptors control cannabinoid CB1 receptor-mediated inhibition of striatal glutamatergic neurotransmission.  J. Neurochem., 116:273–280.

301. Moreno E, Vaz SH, Cai N-S, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI, McCormick PJ, Lluis C, Franco R, Ribeiro JA, Sebastiao AM and Ferre S  (2011)  Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus.  J. Neurosci., 31:7412–7423.

300. Morini R, Mlinar B, Baccini G, Corradetti R  (2011)  Enhanced hippocampal long-term potentiation following repeated MDMA treatment in Dark–Agouti rats.  Eur. Neuropsychopharmacology,  21:80-91.

299. Nistico R, Dargan SL, Amici M, Collingridge GL and Bortolotto ZA  (2011)  Synergistic interactions between kainate and mGlu receptors regulate bouton Ca21 signalling and mossy fibre LTP.  Scientific Reports, Volume:1, Article number:103 DOI:doi:10.1038/srep00103.

298. Rammes G, Hasenjäger A, Sroka-Saidi K, Deussing JM, Parsons CG  (2011)  Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of b-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.  Neuropharmacology, 60:982-990.

297. Ren W-J, Liu Y, Zhou L-J, Li W, Zhong Y, Pang R-P, Xin W-J, Wei X-H, Wang J, Zhu H-Q, Wu C-Y, Qin Z-H, Liu G and Liu X-G  (2011)  Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-a in Rodents.  Neuropsychopharmacology, 36:979–992.

296. Spalloni A, Origlia N, Sgobio C, Trabalza A, Nutini M, Berretta N, Bernardi G, Domenici L, Ammassari-Teule M and Longone P  (2011)  Postsynaptic Alteration of NR2A Subunit and Defective Autophosphorylation of alphaCaMKII at Threonine-286 Contribute to Abnormal Plasticity and Morphology of Upper Motor Neurons in Presymptomatic SOD1G93A Mice, a Murine Model for Amyotrophic Lateral Sclerosis.  Cerebral Cortex, 21:796-805.

295. Traini C, Pedata F, Cipriani S, Mello T, Galli A, Giovannini MG, Cerbai F, Volpini R, Cristalli G and Pugliese AM  (2011)  P2 receptor antagonists prevent synaptic failure and extracellular signal-regulated kinase12 activation induced by oxygen and glucose deprivation in rat CA1 hippocampus in vitro.  Eur. J. Neurosci., 33:2203–2215.

294. Venerosi A, Martire A, Rungi A, Pieri M, Ferrante A, Zona C, Popoli P and Calamandrei G  (2011)  Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis.  Mol. Nutr. Food Res., 55:541–552.

293. Zhou L-J, Yang T, Wei X, Liu Y, Xin W-J, Chen Y, Pang R-P, Zang Y, Li Y-Y and Liu X-G  (2011)  Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat.  Brain, Behavior, and Immunity, 25:322–334.

2010

292. Assaife-Lopes N, Sousa VC, Pereira DB, Ribeiro JA, Chao MV, Sebastião AM (2010)  Activation of Adenosine A2A Receptors Induces TrkB Translocation and Increases BDNF-Mediated Phospho-TrkB Localization in Lipid Rafts: Implications for Neuromodulation.  J. Neurosci., 30:8468-8480.

291. Bouet V, Freret T, Dutar P, Billard J-M and Boulouard M  Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals.  Mechanisms of Ageing and Development, 132:240–248.

290. Ferrante A, Martire A, Armida M, Chiodi V, Pezzola A, Potenza RL, Domenici MR, Popoli P  (2010)  Influence of CGS 21680, a selective adenosine A(2A) receptor agonist, on NMDA receptor function and expression in the brain of Huntington's disease mice.  Brain Res., 1323:184-191.

289. Jang H-J, Cho K-H, Park S-W, Kim M-J, Yoon SH and Rhie D-J  (2010)  Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex.  Korean J Physiol Pharmacol., 14:337-343.

288. Jo J, Son GH, Winters BL, Kim MJ, Whitcomb DJ, Dickinson BA, Lee Y-B, Futai K, Amici M, Sheng M, Collingridge GL and  Cho K  (2010)  Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.  Nature Neuroscience, 13:1216-1226.

287. Kim J, Song B, Hong I, Kim J, Lee J, Park S, Eom JY, Lee CJ, Lee S and Choi S  (2010)  Reactivation of Fear Memory Renders Consolidated Amygdala Synapses Labile.  J. Neurosci., 30:9631-9640.

286. Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M  (2010)  Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization.  Cell, 141:859-871.

285. Martinez-Coria H, Green KN, Billings LM, Kitazawa M, Albrecht M, Rammes G, Parsons CG, Gupta S, Banerjee P, LaFerla FM  (2010)  Memantine Improves Cognition and Reduces Alzheimer's-Like Neuropathology in Transgenic Mice.  Am J. Pathology, 176:870-880.

284. Martire A, Ferrante A, Potenza RL, Armida M, Ferretti R, Pezzola A, Domenici MR, Popoli P  (2010)  Remodeling of striatal NMDA receptors by chronic A(2A) receptor blockade in Huntington's disease mice.  Neurobiol. Disease, 37:99-105.

283. Nash JE, Appleby VJ, Correa SAL, Wu H, Fitzjohn SM, Garner CC, Collingridge GL, Molnar E  (2010)  Disruption of the interaction between myosin VI and SAP97 is associated with a reduction in the number of AMPARs at hippocampal synapses.  J. Neurochem., 112:677-690.

282. Origlia N, Bonadonna C, Rosellini A, Leznik E, Arancio (2010), ShiDu Yan S and Domenici L  (2010)  Microglial Receptor for Advanced Glycation End Product-Dependent Signal Pathway Drives β-Amyloid-Induced Synaptic Depression and Long-Term Depression Impairment in Entorhinal Cortex  J. Neurosci., 30:11414-11425.

281. Valderrama-Gonzalez GD, Gasson MN, Warwick K and Whalley BJ  (2010)  Prosthesis grasp reflex via peripheral nerve control — An in vitro study. Cybernetic Intelligent Systems (CIS), 2010 IEEE 9th International Conference on,  p 1-6.

280. Zhong Y, Zhou L-J, Ren W-J, Xin W-J, Li Y-Y, Zhang T, Liu X-G  (2010)  The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α.  Brain, Behavior & Immunity, 24:874–880.

279. Zhou L-J, Ren W-J, Zhong Y, Yang T, Wei X-H, Xin W-J, Liu C-C, Zhou L-H, Li Y-Y, Liu X-G  (2010)  Limited BDNF contributes to the failure of injury to skin afferents to produce a neuropathic pain condition.  Pain, 148:148-157.

2009

278. Ahmed Z, Wieraszko A  (2009)  The Influence of Pulsed Magnetic Fields (PMFs) on Nonsynaptic Potentials Recorded From the Central and Peripheral Nervous Systems In Vitro.  Bioelectromagnetics, 30:621-630.

277. Amantea D, Marrone MC, Nistico R, Federici M, Bagetta G, Bernardi G, Mercuri NB  (2009)  Oxidative Stress in Stroke Pathophysiology: Validation of Hydrogen Peroxide Metabolism as a Pharmacological Target to Afford Neuroprotection.  Conference Information: Workshop on Apoptosis in Biology and Medicine, SEP 12-15, 2008 Tohoku Pharmaceut Univ, Sendai, JAPAN.  Advances in Neuropharmacology  Book Series: International Review of Neurobiology, 85:363-+.

276. Colotta V, Lenzi O, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Traini C, Pedata F, Morizzo E and  Moro S  (2009)  Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies.  J. Med. Chem., 52:2407–2419.

275. Dickinson BA, Jo J, Seok H, Son GH, Whitcomb DJ, Davies CH, Sheng M, Collingridge GL, Cho K  (2009)  A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-α.  Mol. Brain, 2:18 (12 pages).

274. Etherington LAV, Patterson GE, Meechan L, Boison D, Irving AJ, Dale N, Frenguelli BG  (2009)  Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.  Neuropharmacol., 56:429-437.

273. Gurevicius K, Kuang F, Stoenica L, Irintchev A, Gureviciene I, Dityatev A, Schachner M, Tanila H  (2009) Genetic Ablation of Tenascin-C Expression Leads to Abnormal Hippocampal CA1 Structure and Electrical Activity In Vivo.  Hippocampus, 19:1232-1246.

272. Haseneder R, Kratzer S, von Meyer L, Eder M, Kochs E, Rammes G  (2009)  Isoflurane and sevoflurane dose-dependently impair hippocampal long-term potentiation.  Eur. J. Pharmacol., 623:47-51.

271. Jang HJ, Cho KH, Kim HS, Hahn SJ, Kim MS, Rhie DJ  (2009)  Age-Dependent Decline in Supragranular Long-Term Synaptic Plasticity by Increased Inhibition During the Critical Period in the Rat Primary Visual Cortex.  J. Neurophysiol., 101:269-275.

270. Krüger K, Straub H, Hirner AV, Hippler J, Binding N and Muβhoff U  (2009)  Effects of monomethylarsonic and monomethylarsonous acid on evoked synaptic potentials in hippocampal slices of adult and young rats.  Toxicology and Applied Pharmacol., 236:115–123.

269. Moult PR, Milojkovic B and Harvey J  (2009)  Leptin reverses long-term potentiation at hippocampal CA1 synapses.  J. Neurochem., 108:685-696.

268. Pugliese AM, Traini C, Cipriani S, Gianfriddo M, Mello T, Giovannini MG, Galli A and Pedata F  (2009)  The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices.  Br. J. Pharmacol., 157:818-830.

267. Origlia N, Capsoni S, Cattaneo A, Fang F, Arancio O, Yan SD, Domenici L  (2009)  A beta-Dependent Inhibition of LTP in Different Intracortical Circuits of the Visual Cortex: The Role of RAGE.  J. Alzheimers Disease, 17:59-68.

266. Sawallisch C, Berhorster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S,  Kindler S, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G, Kreienkamp, HJ  (2009)   The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity.  J. Biol. Chem., 284:9225-9236.

265. Serpa A, Ribeiro JA, Sebastiao AM  (2009)  Cannabinoid CB1 and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission.  Eur. J. Pharmacol., 623:41-46.

264. Sheroziya MG, von Bohlen und Halbach O, Unsicker K, Egorov AV  (2009)  Spontaneous Bursting Activity in the Developing Entorhinal Cortex.  J. Neurosci., 29:12131-12144.

263. Tebano MT, Martire A, Chiodi V, Pepponi R, Ferrante A, Domenici MR, Frank C, Chen J-F, Ledent C, Popoli P  (2009)  Adenosine A(2A) receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum.  J. Neurochem., 110:1921-1930.

2008

262. Ahmeda Z, Wieraszko A  (2008)  The mechanism of magnetic field-induced increase of excitability in hippocampal neurons.  Brain Res., 1221:30–40.

261. Al-Hayani AA  (2008)  In Vitro Anticonvulsant Action of 2-Arachidonyl Glycerol.  JKAU: Med. Sci., 14:27-36.

260. Bortolotto ZA, Collett VJ, Conquet F, Jia Z  and Collingridge GL  (2008)  An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity.  Neuropharmacol., 55:454–458.

259. Colotta V, Catarzi D, Varano F, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Traini C, Pugliese AM, Pedata F, Morizzod E and Morod S  (2008)  Synthesis, ligand–receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a] quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.  Bioorganic & Medicinal Chem., 16:6086–6102.

258. Errico F, Nistico R, Palma G, Federici M, Affuso A, Brilli E, Topo E, Centonze D, Bernardi G, Bozzi Y, D'Aniello A, Di Lauro R, Mercuri NB and Usiello A  (2008)  Increased levels of D-aspartate in the hippocampus enhance LTP but do not facilitate cognitive flexibility.  Mol. Cell. Neurosci., 37:236–246.

257. Fontinha BM, Diogenes MJ, Ribeiro JA, Sebastiao AM  (2008)  Enhancement of long-term potentiation by brain-derived neurotrophic factor requires adenosine A2A receptor activation by endogenous adenosine.  Neuropharmacol., 54:924-933.

256. Ishikawa Y, Horii Y, Tamura H and Shiosaka S  (2008)  Neuropsin (KLK8)-Dependent and -Independent Synaptic Tagging in the Schaffer-Collateral Pathway of Mouse Hippocampus.  J. Neurosci., 28:843–849.

255. Hartley DM, Zhao C, Speier AC, Woodard GA, Li S and Walz T  (2008)  Transglutaminase Induces Protofibril-like Amyloid β-Protein Assemblies That Are Protease-resistant and Inhibit Long-term Potentiation.  J. Biol. Chem., 283:16790-16800.

254. Maggio N, Shavit E, Chapman J and Segal M  (2008)  Thrombin Induces Long-Term Potentiation of Reactivity to Afferent Stimulation and Facilitates Epileptic Seizures in Rat Hippocampal Slices: Toward Understanding the Functional Consequences of Cerebrovascular Insults.  J. Neurosci., 28:732–736.

253. Massey PV, Phythian D, Narduzzo K, Warburton EC, Brown MW, Bashir ZI  (2008)  Learning-specific changes in Long-Term Depression in adult perirhinal cortex.  J. Neurosci., 28:7548-7554.

252. Mistry RB, Isaac JTR and Crabtree JW  (2008)  Two differential frequency-dependent mechanisms regulating tonic firing of thalamic reticular neurons.  Eur.J. Neurosci., 27:2643–2656.

251. Mlinar B, Mascalchi S, Morini R, Giachi F and Corradetti R  (2007)  MDMA Induces EPSP–Spike Potentiation in Rat Ventral Hippocampus In Vitro Via Serotonin and Noradrenaline Release and Coactivation of 5-HT4 and b1 Receptors.  Neuropsychopharmacol., 33:1464-1475.

250. Moult PR, Correa SAL, Collingridge GL, Fitzjohn SM and Bashir ZI  (2008)  Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression.  J. Physiol. 586:2499-2510.

249. Origlia N, Righi M, Capsoni S, Cattaneo A, Fang F, Stern DM, Chen JX, Schmidt AM, Arancio O, Yan SD, and Domenici L  (2008)  Receptor for Advanced Glycation End Product-Dependent Activation of p38 Mitogen-Activated Protein Kinase Contributes to Amyloid--Mediated Cortical Synaptic Dysfunction.  J. Neurosci., 28:3521–3530.

248. Riekki R, Pavlov I, Tornberg J, Lauri SE, Airaksinen MS and Taira T  (2008)  Altered synaptic dynamics and hippocampal excitability but normal long-term plasticity in mice lacking hyperpolarizing GABAA receptor-mediated inhibition in CA1 pyramidal neurons.  J Neurophysiol 99:3075–3089.

247. Tanaka K and Augustine GJ  (2008)  A Positive Feedback Signal Transduction Loop Determines Timing of Cerebellar Long-Term Depression.  Neuron, 59:608-620.

246. Tebano MT; Martire A; Potenza RL; Gro C; Pepponi R; Armida M; Domenici MR; Schwarzschild MA; Chen JF; Popoli P  (2008)  Adenosine A2A receptors are required for normal BDNF levels and BDNF-induced potentiation of synaptic transmission in the mouse hippocampus.  J. Neurochem., 104:279-286.

245. Vlachos A, Maggio N and Segal M  (2008)  Lack of Correlation Between Synaptopodin Expression and the Ability to Induce LTP in the Rat Dorsal and Ventral Hippocampus.  Hippocampus, 18:1–4.

244. Wall MJ, Wigmore G, Lopatar J, Frenguelli BG and Dale N (2008)  The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition.  Neuropharmacol., 55:1251–1258.

243.  Xie W, Ramakrishna N, Wieraszko A, Hwang YW  (2008)  Promotion of Neuronal Plasticity by (–)-Epigallocatechin-3-Gallate.  Neurochem. Res., 33:776–783.

242. Zucchini S, Buzzi A, Barbieri M, Rodi D, Paradiso B, Binaschi A, Coffin JD, Marzola A, Cifelli P, Belluzzi O and Simonato M  (2009)  FGF-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-Induced Cell Loss.  J. Neurosci., 28:13112-13124.

2007

241. Bartlett TE, Bannister NJ, Collett VJ, Dargan SL, Massey PV, Bortolotto ZA, Fitzjohn SM, Bashir ZI, Collingridge GL and Lodge D  (2007)  Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.  Neuropharmacol., 52:60-70.

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106. Cho K, Brown MW, Bashir ZI  (2002)  Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex.  J. Physiol. 540:895-906.

105. Clarke VRJ, Collingridge GL  (2002)  Characterisation of the effects of ATPA, a GLU(K5) receptor selective agonist, on excitatory synaptic transmission in area CA1 of rat hippocampal slice.  Neuropharmacol. 42:889-902.

104. Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, Isaac JTR  (2002)  Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.  Nature Neurosci., 5:835-836.

103. Garden DLF, Kemp N, Bashir ZI  (2002)  Differences in GABAergic transmission between two inputs into the perirhinal cortex. Eur. J. Neurosci., 16:437-444.

102. Kidd FL, Coumis U, Collingridge GL, Crabtree JW, Isaac JTR  (2002)  A presynaptic kainate receptor is involved in regulating the dynamic properties of thalamocortical synapses during development.  Neuron 34:635-646.

101. Morton RA, Kuenzi FM, Fitzjohn SM, Fitzjohn SM, Rosahl TW, Smith D, Zheng H, Shearman M, Collingridge GL and Seabrook GR  (2002)  Impairment in hippocampal long-term potentiation in mice underexpressing the Alzheimer's disease related gene presenilin-1.  Neurosci. Lett. 319:37-40.

100. Moult PR, Schnabel R, Kilpatrick IC, Bashir ZI, Collingridge GL  (2002)  Tyrosine dephosphorylation underlies DHPG-induced LTD.  Neuropharmacol. 43:175-180.

99. Smolders I, Bortolotto ZA, Clarke VRJ, Warre R, Khan GM, O'Neill MJ, Ornstein PL, Bleakman D, Ogden A, Weiss B, Stables JP, Ho KH, Ebinger G, Collingridge GL, Lodge D, Michotte Y  (2002)  Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.  Nature Neurosci., 5:796-804.

98. Al-Hayani A and Davies SN  (2002)  Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature dependent.  Eur. J. Pharmacol., 442:47-54.

97. Cunha RA, Coelho JE, Costenla AR, Lopes LV, Parada A, de Mendonca A, Sebastiao AM, Ribeiro JA  (2002)  Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.  Pharmacol. Toxicol. 90:208-213.

96. Kaksonen M, Pavlov I, Voikar V, Lauri SE, Hienola A, Riekki R, Lakso M, Taira T, Rauvala H  (2002)  Syndecan-3-deficient mice exhibit enhanced LTP and impaired hippocampus-dependent memory.  Mol. Cell Neurosci. 21:158-172.

95. Lopes LV, Cunha RA, Kull B, Fredholm BB and Ribeiro JA  (2002)  Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.  Neuroscience, 112:319-329.

94. Maffei A, Prestori F, Rossi P, Taglietti V and D'Angelo E  (2002)  Presynaptic current changes at the mossy fiber - granule cell synapse of cerebellum during LTP.  J. Neurophysiol., 88:627-638..

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92. Pesavento E, Capsoni S, Domenici L, Cattaneo A  (2002)  Acute cholinergic rescue of synaptic plasticity in the neurodegenerating cortex of anti-nerve-growth-factor mice.  Eur. J. Neurosci., 15:1030-1036.

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90. Amet LEA, Lauri SE, Hienola A, Croll SD, Lu Y, Levorse JM, Prabhakaran B, Taira T, Rauvala H and Vogt TF  (2001)  Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule.  Mol. Cell Neurosci., 17:1014-1024.

89. Buckby LE and Lacey MG  (2001)  Depression of excitatory cortico-nucleus accumbens synaptic transmission in rat brain slices by dopamine, but not adenosine, depends upon intracortical mechanisms.  Exp. Brain Res., 141:560-566.

88. Buckby LE and Lacey MG  (2001)  Epileptiform activity in the nucleus accumbens induced by GABAA receptor antagonists in rat forebrain slices is of cortical origin.  Exp. Brain Res., 141:146-152.

87. Bukalo O, Schachner M and Dityatev A  (2001)  Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of Tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus.  Neuroscience, 104:359-369.

86. Cho K, Aggleton JP, Brown MW and Bashir ZI (2001)  An experimental test of predictions concerning the role of calcium in determining synaptic strength.  J. Physiol (London), 532:459-466.

85. Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL and Seabrook GR   (2001)  Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that over-express the human APP695SWE mutant form of amyloid precursor protein.  J. Neurosci, 21:4691-4698.

84. Fitzjohn SM, Palmer MJ, May JER, Neeson A, Morris SAC and Collingridge GL (2001)  A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro.  J Physiol (Lond), 537: 421-430.

83. Fitzjohn SM, Pickard L, Duckworth JK, Molnar E, Henley JM, Collingridge GL and Noel J   (2001)  An electrophysiological characterization of long-term potentiation in cultured dissociated hippocampal neurones.  Neuropharmacol., 41:693-699.

82. Jacoby S, Sims RE and Hartell NA  (2001)  Nitric oxide is required for the induction and heterosynaptic spread of long-term potentiation in rat cerebellar slices.  J. Physiol., 535:825-839

81. Kalikulov D, Ayar A, Nuritova F, Frenguelli BG, McClelland D, Martin DJ, Davidson I and Scott RH  (2001). Venom from Anemesia species of spider modulates high voltage-activated Ca2+ currents from rat cultured sensory neurones and excitatory postsynaptic currents from rat hippocampal slices. Cell Calcium 30:212-221.

80. Kim H-S, Kim H-S, Hahn SJ, Kim M-J, Yoon SH, Jo Y-H, Kim M-S and Rhie D-J  (2005)  Effects of fluoxetine on the induction of long-term potentiation in rat frontal cortex.  Korean J. Physiol Pharmacol., 8:295-300.

79. Lauri SE, Bortolotto ZA, Bleakman D, Ornstein PL, Lodge D, Isaac JTR and Collingridge GL  (2001)  A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP.  Neuron, 32:697-709.

78. Lauri SE, Delany C, Clarke VRJ, Bortolotto ZA, Ornstein PL, Isaac JTR and Collingridge GL  (2001)  Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses.  Neuropharmacology 41: 907-915.

77. Kidd FL and Isaac JTR  (2001)  Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: Role of glutamate clearance.  J Neurophysiol. 86:1139-1148.

76. Massey PV, Bhabra G, Cho K, Brown MW, Bashir ZI  (2001)  Activation of muscarinic receptors induces protein synthesis-dependent long-lasting depression in the perirhinal cortex.  Eur. J. Neurosci., 14:145-152.

75. Pearson T, Nuritova F, Caldwell D, Dale N and Frenguelli BG  (2001)  A depletable pool of adenosine in area CA1 of the rat hippocampus.  J. Neurosci., 21:2298-2307.

74. Schnabel R, Kilpatrick IC and Collingridge GL  (2001)  Protein phosphatase inhibitors facilitate DHPG-induced LTD in the CA1 region of the hippocampus.  Br. J. Pharmacol., 132:1095-1101.

73. Sebastiao AM, de Mondonca A, Moreira T and Ribeiro JA (2001)  Activation of synaptic NMDA receptors by action potential-dependent release of transmitter during hypoxia impairs recovery of synaptic transmission on reoxygenation.   J. Neurosci., 21:8564-8571.

72. Tang J, Wotjak CT, Wagner S, Williams G, Schachner M and Dityatev A  (2001)  Potentiated amygdaloid auditory-evoked potentials and freezing behavior after fear conditioning in mice. Brain Res., 919:232-241.

2000

71. Al-Hayani A and Davies SN  (2000)  Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated.  Br. J. Pharmacol., 131:663-665.

70. Berretta N, Rossokhin AV, Kasyanov AM, Sokolov MV, Cherubini E and Voronin LL  (2000)  Postsynaptic hyperpolarization increases the strength of AMPA-mediated synaptic transmission at large synapses between mossy fibers and CA3 pyramidal cells.  Neuropharmacol., 39:2288-2301.

69. Bortolotto ZA and Collingridge GL (2000)  A role for protein kinase C in a form of metaplasticity that regulates the induction of long-term potentiation at CA1 synapses of the adult rat hippocampus.  Eur. J. Neurosci., 12:4055-4062.

68. Cho K, Kemp N, Noel J, Aggleton JP, Brown MW and Bashir ZI (2000)  A new form of long-term depression in the perirhinal cortex.  Nature Neurosci.,  3:150-156.

67. Coelho JE, de Mendonca A and Ribeiro JA  (2000)  Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices.  Brain Res., 869:158-165.

66. Cunha RA, Almeida T and Ribeiro JA  (2000)  Modification by aracidonic acid of extracellular adenosine metabolism and neuromodulatory action in the rat hippocampus.  J. Biol. Chem., 275:37572-37581.

65. Cunha RA and Ribeiro JA  (2000)  Adenosine A(2A) receptor facilitation of synaptic transmission in the CA1 area of the rat hippocampus requires protein kinase C but not protein kinase A activation.  Neurosci. Lett., 289:127-130.

64. Dale N, Pearson T and Frenguelli BG  (2000)  Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice.  J. Physiol. (Lond.), 526:143-155.

63. Daw MI, Chittajallu R, Bortolotto ZA, Dev KK, Duprat F, Henley JH, Collingridge GL and Isaac JTR  (2000)  PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.  Neuron, 28:873-886.

62. Doherty AJ, Palmer MJ, Bortolotto ZA, Hargreaves A, Kingston AE, Ornstein PL, Schoepp DD, Lodge D and Collingridge GL  (2000)  A novel, competitive mGlu5 receptor antagonist (LY344545) blocks DHPG-induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices.  Br. J. Pharmacol., 131:239-244.

61. Eckhardt M, Bukalo O, Chazal G, Wang L, Goridis C, Schachner M, Gerardy-Schahn R, Cremer H and Dityatev A (2000)  Mice Deficient in the polysialyltransferase ST8SialV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity.  J. Neurosci., 20:5234-5244.

60. Fitzjohn SM, Morton RA, Kuenzi F, Davies CH, Searbook GR and Collingridge GL  (2000)  Similar levels of long-term potentiation in amyloid precursor protein-null and wild-type mice in the CA1 region of picrotoxin treated slice.  Neurosci Lett., 288:9-12.

59. Frankiewcz T, Pilc A and Parsons CG  (2000)  Differential effects of NMDA-receptor antagonists on long-term potentiation and hypoxic/hypoglycaemic excitotoxicity in hippocampal slices.  Neuropharmacol., 39:631-642.

58. Kasyanov AM, Maximov VV, Byzov AL, Berretta N, Sokolov MV, Gasparini S, Cherubini E, Reymann KG and Voronin LL (2000)  Differences in amplitude-voltage relations between minimal and composite mossy fibre responses of rat CA3 hippocampal neurons support the existence of intrasynaptic ephaptic feedback in large synapses.  Neurosci.  101:323-336. .

57. Kemp N, McQueen J, Faulkes S and Bashir ZI  (2000)  Different forms of LTD in the CA1 region of the hippocampus: role of age and stimulus protocol.  Eur. J. Neurosci., 12:360-366.

56. Kidd FL and Isaac JTR  (2000)  Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.  Neuropharmacol., 39:725-732.

55. Lauri SE, Taira T and Rauvala H  (2000)  High-frequency synaptic stimulation induces association of fyn and c-src to distinct phosphorylated components.  Neuroreport, 11:997-1000.

54.  Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, Inouye M, Yakagishi Y, Augustine GJ and Kano M (2000)  Local calcium release in dendritic spines required form long-term synaptic depression.  Neuron, 28:233-244.

53.  Pesavento E, Margotti E, Righi M, Cattaneo A and Domenici L  (2000)  Blocking the NGF-TrkA interaction rescues the developmental loss of LTP in the rat visual cortex: Role of the cholinergic system.  Neuron, 25:165-175.

52.  Pearson T and Frenguelli BG  (2000)  Volume-regulated anion channels do not contribute extracellular adenosine during the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus.  Eur. J. Neurosci., 12:3064-3066.

51.Ribar TJ, Rodriguiz RM, Khiroug L, Wetsel WC, Augustine GJ and Means AR  (2000)  Cerebellar defects in Ca2+/Calmodulin kinase IV-deficient mice. J. Neurosci. 20:RC107(1-5).

50. Ross FM, Cassidy J, Wilson M, and Davies SN (2000) Developmental regulation of hippocampal excitatory synaptic transmission by metabotropic glutamate receptors. Br. J. Pharmacol., 131:453-464.

49. Ross FM, Gwyn P, Spanswick D and Davies SN (2000)  Carbenoxolone depresses spontaneous epileptiform activity in the CA1 region of rat hippocampal slices.  Neuroscience, 100:789-796.

48. Sebastiao AM, Macedo MP and Riveiro JA  (2000)  Tonic activation of A2A adenosine receptors unmasks, and of A1 receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus.  Br. J. Pharmacol., 129:374-380.

47. Sebastiao AM, Cunha RA, de Mendonca A and Riveiro JA  (2000)  Modification of adenosine modulation of synaptic transmission in the hippocampus of aged rats.  Br. J. Pharmacol., 131:1629-1634.

46. Sermasi E, Margotti E, Cattaneo A and Domenici L  (2000)  Trk B signalling controls LTP but not LTD expression in the developing rat visual cortex.  Eur. J. Neurosci., 12:1411-1419.

45. Tolchard S, Clarke G, Collingridge GL and Fitzjohn SM  (2000)  Modulation of synaptic transmission in the rat ventral septal area by the pharmacological activation of metabotropic glutamate receptors.  Eur. J. Neurosci., 12:1843-1847.

44. Wang SS, Khiroug L and Augustine GJ. Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc. Natl. Acad. Sci. 97:8635-8640.

43. Ziakopoulos Z, Brown MW and Bashir ZI  (2000)  GABAB receptors mediate frequency-dependent depression of excitatory potentials in rat perirhinal cortex in vitro.  Eur. J. Neurosci., 12:803-809.

1999

42. Berretta N, Rossokhin AV, Cherubini E, Astrelin AV and Voronin LL (1999) Long-term synaptic changes induced by intracellular tetanization of CA3 pyramidal neurons in hippocampal slices from juvenile rats. Neuroscience, 93:469-477.

41. Bortolotto ZA, Clarke VRJ, Delany CM, Parry MC, Vignes M, Hoo KH, Miu P, Brinton B, Fantaske R, Ogden A, Gates M, Ornstein PL, Lodge D, Bleakman D and Collingridge GL (1999) Kainate receptors are involved in synaptic plasticity. Nature, 402:297-301.

40. Bortolotto ZA and Collingridge GL (1999) Evidence that a novel metabotropic glutamate receptor mediates the induction of long-term potentiation at CAI synapses in the hippocampus. Biochem. Soc. Trans., 27:170-174.

39. Fitzjohn SM, Kingston AE, Lodge D and Collingridge GL (1999) DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterization and sensitivity to novel mGlu receptor antagonists. Neuropharmacol., 38:1577-1583.

38. Frankiewcz T and Parsons CG  (1999)  Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices.  Neuropharmacol., 38:1253-1259.

37. Kemp N and Bashir ZI (1999) Induction of LTD in the adult hippocampus by the synaptic activation of AMPA/kainate and metabotropic glutamate receptors. Neuropharmacol., 38:495-504.

36. Kidd FL and Isaac JTR (1999) Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses. Nature, 400:569-573.

35. Luthi A, Chittajallu R, Duprat F, Palmer MJ, Benke TA, Kidd FL, Henley JM, Isaac JTR and Collingridge GL (1999) Hippocampal LTD expression involves a pool of AMPARs regulated by the NSF GluR2 interaction. Neuron, 24:389-399.

34. McCaffery B, Cho D, Bortolotto ZA, Aggleton JP, Brown MW, Conquet F, Collingridge GL and Bashir ZI (1999) Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro. Neuroscience, 93:977-984.

33. Parsons CG, Danysz W, Bartmann A, Spielmanns P, Frankiewicz T, Hesselink M, Eilbacher B and Quack G  (1999)  Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo.  Neuropharmacol., 38:85-108.

32. Schnabel R, Kilpatrick IC and Collingridge GL  (1999)  An investigation into signal transduction mechanisms involved in DHPG-induced LTD in the CA1 region of the hippocampus.  Neuropharmacol.,  38:1585-1596.

31. Schnabel R, Palmer MJ, Kilpatrick IC and Collingridge GL  (1999)  A CaMKII inhibitor, KN-62, facilitates DHPG-induced LTD in the CA1 region of the hippocampus. Neuropharmacol., 38:605-608.

30. Sermasi E, Tropea D. and Domenici L  (1999)  Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience.  Dev. Brain Res., 113:61-65.

29. Siarey RJ, Carlson EJ, Epstein CJ, Balbo A, Rapoport SI and Galdzicki Z (1999) Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacol., 38:1917-1920..

28. Ziakopoulos Z, Tillett CW, Brown MW and Bashir ZI  (1999)  Input- and layer-dependent synaptic plasticity in the rat perirhinal cortex in vitro. Neuroscience, 92:459-472.

1998

27. Avignone E, Molnar M, Berretta N, Casamenti F, Prosperi C, Ruberti F, Cattaneo A and Cherubini E  (1998)  Cholinergic function in the hippocampus of juvenile rats chronically deprived of NGF. Dev. Brain Res., 109:137-147.

26. Berretta N. and Cherubini E. (1998) A novel form of long-term depression in the CA1 area of the adult rat hippocampus independent of glutamate receptors activation. Eur. J. Neurosci., 10:2957-2963.

25. Benke TA, Luthi A, Isaac JTR and Collingridge GL (1998) Modulation of AMPA receptor unitary conductance by synaptic activity. Nature, 393:793-797.

24. Bortolotto ZA and Collingridge GL (1998) Involvement of calcium/calmodulin-dependent protein kinases in the setting of a molecular switch involved in hippocampal LTP. Neuropharmacol., 37:535-544.

23. Crabtree JW, Collingridge GL and Isaac JTR (1998) A new intrathalamic pathway linking modality-related nuclei in the dorsal thalamus. Nature Neurosci., 1:389-394.

22. Domenici MR, Berretta N and Cherubini E (1998) Two distinct forms of long-term depression coexist at the mossy fiber-CA3 synapse in the hippocampus during development. PNAS, 95:8310-8315.

21. Fitzjohn SM, Bortolotto ZA, Palmer MJ, Doherty MJ, Doherty AJ, Ornstein PL, Schoepp DD, Kingston AE, Lodge D and Collingridge GL (1998) The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity. Neuropharmacol., 37:1445-1458.

20. Isaac JTR, Luthi A, Palmer MJ, Anderson WW, Benke TA and Collingridge GL (1998) An investigation of the expression mechanism of LTP of AMPA receptor- mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. Neuropharmacol., 37:1399-1410.

19. Johnston AJ, Fraser JR, Jeffrey M and MacLeod NK (1998) Synaptic plasticity in the CA1 area of the hippocampus of scrapie-infected mice. Neurobiol. Disease, 5:188-195.

18. Nishimune A, Isaac JTR, Molnar E, Noel J, Nash SR, Tagaya M, Collingridge GL, Nakanishi S and Henley JM (1998) NSF binding to GluR2 regulates synaptic transmission. Neuron, 21:87-97.

17. Ruberti F, Berretta N, Cattaneo A and Cherubini E (1997) NGF antibodies impair LTD in the mossy fibre-CA3 synapse in the developing hippocampus. Dev. Brain Res., 101: 295-297.

16. Paton GS, Pertwee RG and Davies SN (1998) Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice. Neuropharm., 37:1123-1130.

15. Vignes M, Clarke VRJ, Parry MJ, Bleakman D, Lodge D, Ornstein PL and Collingridge GL (1998) The GluR5 subtype of kainate receptor regulates excitatory synaptic transmission in areas CA1 and CA3 of the rat hippocampus. Neuropharmacol., 37:1269-1277.

1997

14. Doherty AJ, Palmer MJ, Henley JM, Collingridge GL and Jane DE (1997)  (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu(5), but not mGlu(1), receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.  Neuropharmacol., 36:265-267.

13. Harvey J, Palmer MJ, Irving AJ, Clarke VRJ. and Collingridge GL (1996)  NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus. Br. J. Pharmacol., 119:1239-1247.

12. Kemp N and Bashir ZI (1997) A role for adenosine in the regulation of long-term depression in the adult rat hippocampus in vitro. Neurosci. Lett., 225:189-192.

11. Kemp N and Bashir ZI (1997) NMDA receptor-dependent and –independent long-term depression in the CA1 region of the adult rat hippocampus in vitro. Neuropharmacol., 36:397-399.

10. Palmer MJ, Irving AJ, Seabrook GR, Jane DE and Collingridge GL (1997) The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacol., 36:1517-1532.

9. Siarey RJ, Stoll J, Rapoport SI and Galdzicki Z (1997) Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down Syndrome. Neuropharmacol., 36:1549-1554.

8. Vignes M, Bleakman D, Lodge D and Collingridge GL (1997) The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus. Neuropharmacol., 36:1477-1481. 

7. Vignes M and Collingridge GL (1997) The synaptic activation of kainate receptors. Nature, 388:179-182.

1996

6. Bresink I, Benke TA, Collett VJ, Seal AJ, Parsons CG, Henley JM and Collingridge GL (1996) Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells. Br. J. Pharmacol., 119:195-204.

5. Bushell TJ, Jane DE, Tse HW, Watkins JC, Garthwaite J and Collingridge GL (1996)  Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices.  Br. J. Pharmacol., 117:1457-1462.

4. Chittajallu R, Vignes M, Dev KK, Barnes JM, Collingridge GL and Henley JM (1996)  Regulation of glutamate release by presynaptic kainate receptors in the hippocampus.  Nature, 379:78-81.

3. Harvey J, Palmer MJ, Irving AJ, Clarke VRJ and Collingridge GL (1996) NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus. Br. J. Pharmacol., 119:1239-1247.

1995

2. Bushell TJ, Jane DE, Tse HW, Watkins JC, Davies CH, Garthwaite J and Collingridge GL (1995) Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices. Neuropharmacol., 34:.239-241.

1. Vignes M, Clarke VRJ, Davies CH, Chambers A, Jane DE, Watkins JC and Collingridge GL (1995) Pharmacological evidence for an involvement of group-II and group-III mGlurs in the presynaptic regulation of excitatory synaptic responses in the ca1 region of rat hippocampal slices. Neuropharmacol., 34:973-982.